催产素在妇科腹腔镜手术术后镇痛中的临床观察

The Clinical Study of Oxytocin in Postoperative Analgesia of Gynecological Laparoscopic Operation

探讨催产素用于妇科腹腔镜手术术后镇痛的有效性和安全性。将90例患者随机分为3组:A组术后不给予镇痛,B组静脉泵注催产素0.5U/kg,C组静脉泵注舒芬太尼2μg/kg。记录患者术毕1h、6h、12h、24h、48h时VAS疼痛评分、Ramsay镇静评分、HAD焦虑总评分和不良反应发生率等。术毕6h、12h、24h、48h各时点Ramsay评分,A组最小(P<0.05),B组和C组无显著差异;6h^48h各时点VAS评分,A组>B组>C组(P<0.05);24h和48h时焦虑总评分A组>C组>B组(P<0.05)。恶心、呕吐发生率,C组>A组>B组(P<0.05)。催产素能在一定程度上减轻术后疼痛,且兼具缓解焦虑、减轻不良反应的优势,值得临床推广。

To explore the effectiveness and safety of oxytocin in postoperative analgesia of gynecological laparoscopic operation. 90 patients were randomly divided into 3 groups： group A wasn＇t given any analgesia, group B was administered 0.5U/kg oxytocin while group C 2μg/kg sufentanil, both venously. The scores of Visual Analog Scale （VAS） and Ramsay scale at lh, 6h, 12h, 24h, 48h post-operation and total anxiety scores of Hospital Anxiety Depression scale（HAD） at lh, 24h, 48h post-operation were observed as well as the side-effects. Group A obtained the minimum Ramsay scores, however, the maximum VAS and total anxiety scores （P〈0.05）. Oxytocin treatment achieved the minimum total anxiety scores （P〈0.05）. Sufentanil administration achieved the minimum scores of VAS （P〈0.05）. Scores of Ramsay in group B and C were similar. The incidence of nausea and vomiting in group C was the maximum while group B was the minimum （P〈0. 05）. Oxytocin was blessed with mild analgesic effect with less side-effects, which is worthy to be expanded clinically.