血清催产素水平与代谢综合征及其组分的相关性研究

Correlation of serum oxytocin level with metabolic syndrome and its components

目的探讨血清催产素（OT）水平与MS及其各组分的关系。方法选取受试者165例,行75g OGTT及胰岛素释放试验,检测血糖、血脂及OT水平,计算BMI、WHR,采用稳态模型评估胰岛素抵抗指数（HOMA-IR）。结果 （1）随着血清OT水平增高,MS在Q1、Q2、Q3组的患病率逐渐下降（67.3%vs 45.5%vs 32.7%,P〈0.05）,WC、BMI、WHR、FPG、FIns、TG、TC、HOMA-IR降低（P〈0.05）,HDL-C升高（P〈0.01）。与非MS（Non-MS）组相比,MS组血清OT水平下降[（9.94±2.86）vs（8.14±2.18）pg/ml,P〈0.01]。（2）Pearson相关性分析显示,血清OT水平与WC、BMI、FPG、FIns、HbA1c、颈围、WHR、TG、TC、HOMA-IR呈负相关（P〈0.05）,与HDL-C呈正相关（P〈0.01）。（3）多元逐步回归分析显示,BMI、FPG、TG是血清OT水平的影响因素（P〈0.05）。（4）Logistic回归分析显示,OT与MS相关（OR=0.787,95%CI：0.636~0.975）。结论随血清OT水平降低,MS发生率增加,低血清OT水平可能是MS的独立危险因素。

Objective To explore the relationship of serum oxytocin level with MS and its components. Methods A total of 165 subjects were included and divided into three groups by serum oxytocin level as Quartile 1,Quartile 2and Quartile 3.The data of medical history,height,weight,waist circumference,hip circumference and blood pressure were collected.All subjects underwent 75 g OGTT and insulin release test.The index of insulin resistance was calculated by HOMA-IR algorithm The indicators of glucose and blood lipid were also determined.ELISA was adopted to measure serum oxytocin levels. Results（1）With increasing of serum oxytocin levels,the prevalence of MS in Q1,Q2 and Q3gradually decreased as 67.3%,45.5% and 32.7% respectively（P〈0.05）,the values of WC,BMI,WHR,FPG,FIns,TG,TC and HOMA-IR decreased（P〈0.05）,but HDL-C increased（P〈0.01）.Serum oxytocin level in MS group was lower than that in Non-MS group（8.14±2.18 vs 9.94±2.86pg/ml,P〈0.01）.（2）Pearson correlation analysis showed that serum oxytocin level was negatively associated with WC,BMI,FPG,TG,TC and HOMA-IR（P〈0.05）,but positively related with HDL-C（P〈0.01）.（3）Multiple stepwise regression analysis showed that BMI,FPG and TG were independent influencing factors for serum oxytocin level（P〈0.05）.（4）Logistic regression analysis showed that serum oxytocin was associated with MS（OR=0.787,95% CI：0.636~0.975）. Conclusion With decreasing of serum oxytocin level,prevalence of MS is increasing.Low serum oxytocin level may be an independent risk factor for MS.