益气健脾方治疗肺癌患者化疗相关性疲乏的临床研究

Treating Cancer-related Fatigue after Chemotherapy in Lung Cancer Patients by Yiqi Jianpi Recipe:a Clinical Study

目的 观察健脾益气方治疗肺癌患者化疗相关性疲乏的临床疗效。方法 将124例患者按随机数字表法分为治疗组（63例）和对照组（61例）。两组患者根据病情需要均采用既定化疗方案化疗,治疗组从化疗第1天开始口服益气健脾方汤剂,每日1剂,连服2周,对照组不予口服中药汤剂。采用癌性疲乏量表（cancer fatigue scale,CFS）观察两组患者化疗前1天、化疗第3、14天CFS量表各维度评分及量表总分变化,并观察化疗后两组患者骨髓抑制程度及重组人粒细胞集落刺激因子（recombinant human granulocyte colony-stimulating factor,rhG-CFS）用量情况。结果 与本组化疗前1天比较,治疗组化疗第3天和对照组化疗第3、14天情感维度、认知维度、躯体维度评分及量表总分均升高,差异有统计学意义（P〈0.01）;与本组化疗第3天比较,两组化疗第14天情感维度、认知维度、躯体维度评分及量表总分均降低,差异有统计学意义（P〈0.01）。与对照组同期比较,治疗组化疗第3天认知维度评分降低,差异有统计学意义（P〈0.01）,治疗组化疗第14天情感维度、认知维度、躯体维度评分及量表总分均亦降低,差异有统计学意义（P〈0.01）。治疗组化疗后骨髓抑制的发生率为70.97%（44/62）,对照组化疗后骨髓抑制的发生率为68.85%（42/61）,两组比较,差异无统计学意义（χ~2=0.540,P〉0.05）。两组患者rhG-CFS的用量比较,差异亦无统计学意义（χ~2=0.696,P〉O.05）。结论 益气健脾方能明减轻肺癌患者的化疗相关性疲乏,并能明显减轻化疗相关性疲乏对肺癌患者日常生活的影响。

Objective To evaluate the clinical efficacy of Yiqi Jianpi Recipe（YJR） in treating cancer-related fatigue（CRF） after chemotherapy in lung cancer patients.Methods Totally 124 lung cancer patients were assigned to the treatment group（63 cases） and the control group（61 cases） according to random digit table.All patients received pre-set chemotherapy regimens according their conditions.Patients in the treatment group took YJR Decoction from the 1st day of chemotherapy,one dose per day for 2 successive weeks,while those in the control group took no Chinese medical decoction.Changes of each dimensional scoring and the total scoring were observed by cancer fatigue scale（CFS） in the two groups one day before chemotherapy,on the 3rd day and the 14 th day after chemotherapy.The degree of bone marrow depression and recombinant human granulocyte colony-stimulating factor（rhG-CFS） doses were also observed after chemotherapy.Results Compared with one day before chemotherapy in the same group,scorings for emotional,perceptional,and somatologic dimensions,and the total scoring significantly increased on the 3rd day in the treatment group,as well as on the 3rd and the 14 th day in the control group（P0.01）.Scorings for emotional,perceptional,and somatologic dimensions,and the total scoring significantly decreased more at the fourteenth day after chemotherapy than at the 3rd day after chemotherapy（P0.01）.There was statistical difference in the scoring for perceptional dimension at day 3 between the treatment group and the control group（P0.01）.However,scorings for emotional,perceptional,and somatologic dimensions,and the total scoring significantly decreased more at the fourteenth day after chemotherapy in the treatment group,with statistical difference when compared with those in the control group（P0.01）.The occurrence rate of bone marrow depression was 70.97%（44/62） in the treatment group and 68.85%（42/61） in the control group.There was no significant difference in the occurrence rate between the two groups（χ~2=0.540,P0.05）,There was no statistical difference in rhG-CFS doses between the two groups（χ~2=0.696,P0.05）.Conclusion YJD could significantly relieve CRF after chemotherapy in lung cancer patients,and obviously attenuate the effect of CRF on their daily life.