帕罗西汀合并奥氮平治疗强迫症的疗效与安全性

The Effect Observation of Paroxetine Combined with Olanzapine in Treatment of Obsessive-compulsive Disorder

目的:观察帕罗西汀合并奥氮平治疗强迫症的临床效果和不良反应。方法:将80例强迫症患者随机分成两组,每组40例,研究组服用帕罗西汀和奥氮平,对照组单用帕罗西汀,疗程均为8周。采用汉密顿焦虑量表(HAMA)、耶鲁-布朗强迫症状量表(Y-BOCS)评定临床疗效,采用副反应量表(TESS)评定副反应。结果:研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗第8周时两组Y-BOCS、HAMA评分比较差异有统计学意义(P<0.05)。两组TESS评分在治疗第1、2、4、8周末差异均无统计学意义(P>0.05)。结论:帕罗西汀合并奥氮平治疗强迫症可以提高疗效,安全性较好,不会明显增加不良反应。

Objective：To evaluate the clinical efficiency of Paroxetine combined with Olanzapine in treating obsessive-compulsive disorder.Method：80 patients with obsessive-compulsive disorder were randomly divided into study group and control group,40 cases in each group. Paroxetine and Olanzapine were given to the study group,while only paroxetine was given to the control group,the treatment course were 8 weeks.Yale-Brown obsessive compulsive scale （Y-BOCS）,Hamilton anxiety scale（HAMA） were used before treatment and after 8 weeks treatment to assess the efficacy,treatment emergent symptom scale （TESS） was used to assess the side effects.Result：The total effective rate of observation group was higher than that of control group,the difference was significant （P〈0.05）,while after 8 weeks treatment,Y-BOCS,HAMA scores between the two groups had significant difference（P〈0.05）.While after 1,2,4, 8 weeks treatment,TESS scores between the two groups had no significant difference（P〉0.05）.Conclusion：Paroxetine combined with Olanzapine in treatment of obsessive-compulsive disorder can improve therapeutic efficacy,the security is better,not increase adverse reactions.