消化道溃疡患者奥美拉唑代谢相关基因CYP2C19的多态性分布

The Polymorphism Distribution of Omeprazole Mechanism Related CYP2C19 Gene in Patients of Peptic Ulcer

目的:分析奥美拉唑代谢相关基因CYP2C19基因在消化道溃疡患者中的多态性分布。方法:选取消化道溃疡患者23例为研究对象,采用基因芯片的方法检测CYP2C19的基因多态性,并分析CYP2C19基因型总体分布和性别分布。结果:CYP2C19基因型(636GG,681GG)、(636GG,681GA)、(636GA,681GG)、(636GG,681AA)、(636GA,681GA)及(636AA,681GG)携带率分别为39.1%、30.4%、13%、8.7%、8.7%、0;CYP2C19基因快代谢型占39.1%,中代谢型占43.5%,慢代谢型占17.4%;不同性别在CYP2CI9基因分型上差异无统计学意义。结论:检测CYP2C19基因型可为奥美拉唑个体化用药提供指导。

Objective： To investigate the polymorphism distribution of omeprazole mechanism related CYP2C19 gene in patients of peptic ulcer. Method： Twenty-three patients of peptic ulcer were select- ed, then adopting gene chip to test the polymorphism of CYP2C19. Analyzing the general distribution and gender distribution of CYP2C19 genotype. Results： CYP2C19 genotype （636GG, 681GG）, （ 636GG, 681GA）, （ 636GA, 681GG）, （ 636GG, 681AA ） , （ 636GA, 681GA ） and （ 636AA, 681 GG ） carrier rates were respectively 39.1%, 30.4%, 13%, 8.7%, 8.7% , 0;the extensive metabolizer, intermediate metabolizer, poor metabolizer of CYP2C19 gene were 39.1%, 43.5% and 17.4% ; the gender differences in CYP2C19 had no statistical significance. Conclusion： Testing of CYP2C19 might be useful in suggesting medication of omeprazole.