贵阳地区老年人促甲状腺激素水平调查

Investigation of TSH Level of the Elderly in Guiyang

目的：比较贵阳地区老年人群促甲状腺激素（TSH）与成年人群的差异,为建立老年人TSH正常值参考范围提供数据。方法：选择健康体检者3 033例,按年龄分为老年组（〉65岁,n=1 665）和成年组（≤65岁,n=1 368）;取清晨空腹静脉血4 m L,采用电化学发光法测定血清TSH,以中位数（M）和双侧限值（P2.5~P97.5）表示参考范围,建立两组人群男女TSH水平参考范围。结果：两组受检者的TSH值呈偏态分布,女性TSH水平均高于男性,老年组TSH水平均高于成年组,差异有统计学意义（P〈0.05）,建立TSH参考范围为老年男性2.70（0.67~7.03）m IU/L,女性3.28（0.68~8.10）m IU/L;成年男性2.10（0.59~5.86）m IU/L,女性2.81（0.67~6.97）m IU/L。结论：贵阳地区不同性别、不同年龄TSH水平各异。

Objective ： To compare the differences of TSH level of the elderly in Guiyang and to pro- vide the basic data for establishment of normal reference range of TSH for the elderly in Guiyang. Methods： A total of 3 033 cases of healthy medical check-up people were enrolled in this study and divided into older age group （ over 65 years old, 1 665 cases） and adult group （ less than 65 years old, 1 368 cases）. 4 mL early morning fasting venous blood was collected from two groups, and electro- chemiluminescence assay was performed to measure serum TSH level. With median （M） and limits on both sides （ P2.5 ~ P97.5 ） being the reference range, the reference range of TSH level in men and women of two groups was established. Results： The TSH level of two groups appeared partial distribu- tion. The TSH levels in women were generally higher compared with men while TSH levels in older age group were significantly higher than those of adult group （ P 〈 0.05 ）. TSH reference range was as fol- lows ： the elderly men 2.70 （0.67 - 7.03 ） mIU/L, the elderly women 3.28 （0.68 - 8.10） mIU/L, the adult men 2.10 （0.59 ~ 5.86） mIU/L, the adult women 2.81 （0.67 - 6.97） mIU/L. Conclu- sion： The different gender elderly TSH level reference range is successfully established and reveals different TSH level in the elderly people.