左卡尼汀对终末期肾病血液透析患者心脏结构和功能的影响

Effects of L-carnitine on Cardiac Structure and Function in Maintenance Hemodialysis Patients

目的:探讨左卡尼汀对终末期肾病(ESRD)维持性血液透析(MHD)患者心脏结构和功能的影响。方法:将78例MHD患者随机分为两组,对照组予MHD、降压、纠正贫血等常规处理,观察组在此基础上应用左卡尼汀注射液,采用超声心动图观察两组患者治疗前后左室射血分数(LVEF)、左心室心肌质量指数(LVMI)、左心室舒张末内径(LVDd)以及舒张早、晚期最大血流速度比(E/A)。结果:治疗前两组患者超声心动图指标比较差异无统计学差异(P>0.05),观察组治疗后LVEF、E/A明显高于治疗前,LVMI、LVEDD明显低于治疗前,差异有统计学意义(P<0.05);对照组治疗前后上述指标无明显变化(P>0.05)。结论:左卡尼汀可明显改善ESRD MHD患者左心室肥厚,显著提高患者的心功能。

Objective： To investigate the effects of L-carnitine on cardiac structure and function in maintenance hemodialysis （MHD） patients. Methods： Seventy-eight MHD patients were randomly di- vided into two groups, of which the control group was given hemodialysis, blood pressure control, ane- mia correction and other conventional treatment, while the observation group was given L-carnitine in- jection besides above-mentioned treatments in the control group. Then, the echocardiography indicators were observed before and after treatment. Results： Before treatment, there were of no significant differences in the two groups in echocardiographic indices including LVEF, LVMI, LVEDD and E/A （P 〉 0.05 ） ; But after treatment, the LVEF, E/A was significantly improved and LVMI and LVEDD was decreased significantly in the observation group （ P 〈 0.05 ）, while the control group showed no significant change （ P 〉 0.05 ）. Conclusion： The treatment of L-carnitine in maintenance hemodialysis patients can improve the left ventricular hypertrophy, and can significantly improve cardiac function.