甲氨蝶呤合复方甘草酸苷片治疗寻常型银屑病50例临床观察

Efficacy of psoriasis with hexameter combined with compound glycerin tablets treatment

目地:观察甲氨蝶呤联合复方甘草酸苷片治疗寻常型银屑病的临床疗效。方法:选取100例寻常性银屑病患者,分为A组、B组,每组50例。A组在常规治疗中应用甲氨蝶呤,B组在常规治疗中应用甲氨蝶呤及复方甘草酸苷片。对两组治疗前后皮损面积和严重指数(PASI)改善情况、治疗总有效率及药物不良反应发生率进行分析。结果:治疗前两组间PASI比较差异无统计学意义(P>0.05),治疗2个月后,B组PASI明显低于A组(P<0.05);同时两组治疗总有效率也存在差异,以B组更高(P<0.05);此外,药物不良反应发生率比较,两组差异无统计学意义(P>0.05)。结论:寻常型银屑病治疗中联合甲氨蝶呤及复方甘草酸苷片可提高临床疗效。

Objective Hexameter and glycerin sheet value in the treatment of psoriasis vulgar was discussed.Methods 100 pa-tients with psoriasis vulgar were enrolled into two groups A and B,50 cases in each group.A group of conventional treatment hexame-ter,hexameter group B applications in the conventional therapy hexameter and glycerin tablets.Before and after treatment,the lesion area and severity index （PASI）to improve the situation,the total efficiency of the treatment and the incidence of adverse drug reactions were analyzed.Results Before treatment PASI comparison between the two groups was no significant difference （P 〉0.05）,after two months of treatment,group B PASI was significantly lower than group A （P 〈0.05）while the total efficiency of treatment was also differences that higher than group B （P 〈0.05）In addition,the incidence of adverse drug reactions,and no significant difference be-tween the two groups （P 〉0.05）.Conclusion The treatment of psoriasis vulgar in combination with hexameter and glycerin tablets im-prove dclinical outcomes.