可溶性髓系细胞触发受体-1在新生儿坏死性小肠结肠炎诊断与病情判断上的价值

Value of Soluble Triggering Receptor Expressed on Myeloid cells-1 in the Diagnosis of Neonatal Necrotizing Enterocolitis and Illness Judgment

目的探讨血清可溶性髓系细胞触发受体-1（s TREM-1）在诊断新生儿坏死性小肠结肠炎（NEC）及评估病情严重程度的价值。方法选取2013-10～2014-10间在我院收治的120例NEC患儿作为研究组,按照Bell-NEC分级标准修改版分为三期,同时选取同期正常45例新生儿作为对照组。采用酶联免疫吸附实验（ELISA）法测定两组患儿的血清s TREM-1水平,比较两组间及不同分级组间血清s TREM-1浓度的关系。结果研究组血清s TREM-1浓度明显高于对照组,差异具有统计学意义（P〈0.05）;Bell-NEC分级标准组中,血清s TREM-1浓度III期明显高于I期和II期,II期血清s TREM-1浓度也高于I期,差异均具有统计学意义（P〈0.05）。结论血清s TREM-1水平的变化能早期客观的预测NEC的发生及评估病情严重程度。

Objective To discuss the value of Soluble triggering receptor expressed on myeloid cells- 1 in the diagnosis of neonatal necrotizing enterocolitis and illness judgment. Methods 120 children with NEC were selected from October,2013 to October,2014 in the hospital as the research group,and they were divided into three phases according to the Bell- NEC classification standard revision. 45 cases of newborn were selected as control group in the same period of normal. Levels of serum s TREM- 1 of the two groups were determined by the ELISA method,to compare the relationships between different classifications of concentration of serum s TREM- 1 of the two groups. Results Serum concentration s TREM- 1 of the research group was higher than the control group,with statistically significant difference（ P〈0. 05）; Serum concentration s TREM- 1 in phase III were significantly higher than phase I and phase II,phase II of serum s TREM- 1 concentration was higher than phase I in Bell- NEC group classification standard,and the difference had statistically significant（ P〈0. 05）.Conclusion The change of the serum levels of s TREM- 1 can early and objectively predict NEC and assessment of disease severity.