住院患者抗菌药物消耗量与非发酵菌耐药状况的分析

Analysis of antimicrobial consumption and resistance of nonfermentative bacteria in hospitalized patients

目的分析综合抗菌药物管理策略对住院患者抗菌药物消耗量及对非发酵菌耐药的影响。方法回顾性分析2010年-2013年某所综合性医院实施抗菌药物管理程序,对住院患者抗菌药物使用强度和鲍曼不动杆菌及铜绿假单胞菌的耐药率的影响。结果实施综合抗菌药物管理策略后,住院患者总抗菌药物、3代及4代头孢菌素、3代头孢菌素加酶抑制剂、氟喹诺酮的使用强度出现显著性下降,铜绿假单胞菌对头孢他啶的耐药率呈现下降趋势,鲍曼不动杆菌的耐药率无显著变化。结论严格执行综合抗菌药物管理措施可以有效降低住院患者抗菌药物使用强度,可能对铜绿假单胞菌的耐药状况产生有益的影响。

Objective To investigate the effects of antimicrobial stewardship program on the antimicrobial consumption and resistance of nonfermentative bacteria in hospitalized patients. Methods The effects of antimicrohial stewardship program on the antimicrobial consumption and resistance of nonfermentative bacteria in hospitalized patients in 2010-2013 were retrospectively analyzed in a general hospital. Results Compared to before, the 3-and 4-generation cephalosporins, 3GC/^-lactam inhibitors, fluoroquinolones and total antibiotic consumption were significantly reduced after the antimicrobial stewardship program was implemented. Ceftazidime resistance rate of Pseudomonas aeruginosa declined, while resistance rate of Acinetobacter baumannii to each kind of antimicrobials had no significant change. Conclusion Antimicrohial stewardship programs could reduce antimicrobial consumption of hospitalized patients and might benefit the drug resistance status of Pseudomonas aeruginosa.