食管鳞癌组织CADM1 mRNA的表达及临床病理意义被引量：1

Expression and clinicopathological significance of CADM1 mRNA in esophageal squamous cell carcinoma

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摘要目的探讨食管鳞状细胞癌中细胞黏附分子l(CADM1)mRNA的表达及其临床病理学意义。方法采用RT-PCR半定量检测50例食管鳞癌(食管鳞癌组)及其邻近正常食管黏膜(正常黏膜组)CADM1 mRNA的表达。结果食管鳞癌组CADM1 mRNA表达量低于正常黏膜组(0.522±0.247vs.0.871±0.192)(P<0.01)。食管鳞癌组有淋巴结转移患者的CADM1mRNA表达量低于无淋巴结转移者(P<0.01)。CADM1 mRNA表达与食管鳞癌的TNM分期密切相关(P<0.05),而与患者性别、年龄及肿瘤组织学分级无相关性(P>0.05)。结论 CADM1mRNA在正常食管黏膜组织中高表达,而在食管鳞状细胞癌中低表达,提示CADM1表达缺失对在食管鳞状细胞癌的发生、侵袭、转移有一定的作用;检测CADM1mRNA表达对判断食管鳞状细胞癌患者预后有一定价值。 Objective To investigate th expression and clinicopathologic significance of cell adhesion molecule I（CADM1） mRNA in esophageal squamous cell carcinoma（ESCC）. Methods The expression of CADM1 mRNA was detected by serniquan titative RT-PCR in 50 ESCC（group T） and tumor-adjacent normal esophageal tissues（group N）. Results The mRNA expression of CADM1 was lower in gro up T than that in group N （0.522 ± 0. 247 vs. 0.871 ± 0.192 ）（ P〈 0. 01 ）, which in group T was lower in the patients with lymph node metastasis than that in those without（P〈0. 01）. The expression of CADM1 mRNA in group T was closely related to TNM staging（P〈0. 05）, but not significantly related to sex, age and histological grade（P〉0. 05）. Conclusion CADM1 mRNA was lowerly expressed in ESCC. The ｜ack of CADM1 mRNA expression may play an important role in the development,invasion and metastasis of ESCC, which may be used as a indicator for predicting the prognosis of the patients with ESCC.

作者刘宏斌朱燕张晓娟杨其昌沈屹

机构地区南通市第一人民医院病理科

出处《江苏医药》 CAS 2015年第17期2042-2044,共3页 Jiangsu Medical Journal

基金南通市社会事业科技创新与示范项目(HS2013022)

关键词食管鳞状细胞癌细胞黏附分子1 Esophageal squamous cell carcinoma Cell adhesion molecule 1

分类号 R735 [医药卫生—肿瘤]

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