米非司酮联合米索前列醇对带环早孕的药物流产药学分析

Pharmacy analysis of mifepristone combined with misoprostol medical abortion in early pregnancy with a ring

目的 分析米非司酮联合米索前列醇对带环早孕者药物流产的临床效果.方法 回顾性分析枣庄市妇幼保健院2012年1月至2014年1月间收治的98例带环早孕患者的临床资料,根据流产方式的不同,将本组患者按其意愿随机分成对照组和实验组,每组49例.对照组施与手术流产,实验组给予米非司酮联合米索前列醇进行药物流产.评估药物流产的成功率以及两组患者的手术时间、阴道流血量和不良反应发生情况.结果 手术流产的临床有效率为87.76％,药物流产成功流产率为69.39％;实验组患者的手术时间和术中出血量均明显少于对照组（P＜0.05）,且实验组患者不良反应发生率明显低于对照组（P＜0.05）.结论 对于带环早孕患者,给予其米非司酮联合米索前列醇的流产效果好,安全可靠,值得临床推广使用.

Objective To analyze the effects of medical abortion on clinical pregnancy with belt loop given mifepristone and misoprostol.Methods Retrospectively analyzed the clinical data of 98 patients with a ring of early pregnancy in maternity and child care hospital of zaozhuang from January 2012 to January 2014,and randomly divided them into control group and experiment group according to the different methods of abortion and the wishes of patients,with 49 cases in each group.The control group was given surgical abortion and the experiment group was treated with mifepristone for medical abortion.The success rate of medical abortion,the operative time,amount of vaginal bleeding and adverse reactions were assessed and compared.Results The effective clinical surgical abortion rate was 87.76%,and the successful drug abortion rate was 69.39%;The operative time and blood loss in experiment group were significantly less than those in control group （P 〈 0.05）,the incidence of adverse reactions in experiment group was significantly lower than that in control group （P 〈 0.05）.Conclusions Mifepristone combined with misoprostol is a more effective and safe clinical therapy for patients with a ring pregnancy than surgical abortion.