冠心病患者血清生长分化因子-15和脑钠肽及超敏C反应蛋白水平的变化

Changes in serum levels of growth differentiation factor-15, brain natriuretic peptide and high sensitivity C reactive protein in patients with coronary heart disease

目的探讨冠心病患者血清生长分化因子15（GDF-15）、脑钠肽（BNP）、超敏C反应蛋白（hs—CRP）水平的变化。方法选择诊断明确的冠心病患者120例作为观察组，其中，稳定型心绞痛组、不稳定型心绞痛组、急性心肌梗死组各40例。同期健康体检者120例为对照组。测定其血清GDF-15、BNP、hs—CRP水平，并进行对比分析。结果观察组患者血清GDF-15、BNP和hs—CRP水平高于对照组（P〈0．05）；其中，观察组中急性心肌梗死组患者血清GDF-15、BNP和hs—CRP水平最高，其次为不稳定型心绞痛组，最低者为稳定型心绞痛组，组间比较差异有统计学意义（P〈0．05）。Spearman秩相关分析结果显示，GDF-15、BNP、hs—CRP与冠心病呈正相关（r值分别为0．564、0．573和0．586，均P〈0．05）。结论GDF-15、BNP、hs—CRP与冠心病的发生、发展有关。

Objective To explore the changes in serum levels of growth differentiation factor- 15, brain natriuretic peptide and high sensitivity C reactive protein and the clinical significances in patients with coronary heart disease. Methods We selected 120 coronary heart disease （CHD） patients as observation group, including 40 cases with stable angina pectoris （group A）, 40 cases with unstable angina （group B） and 40 cases with acute myocardial infarction （group C）. 120 healthy volunteers were selected as control group. The levels of GDF-15, BNP and hs-CRP were measured and compared. Results The serum levels of GDF-15, BNP and hs-CRP were higher in observation group than in control group （P〈0.05）. In observation group, the levels of GDF-15, BNP and hs- CRP in group C were the highest, followed by the group B and group A （P〈0.05）. Spearman＇s rank correlation analysis showed that GDF-15, BNP and hs-CRP had positive correlations with CHD （ r= 0. 564, 0. 573 and 0. 586,all P〈0.05）. Conclusions GDF-15, BNP and hs-CRP play a certain role in the occurrence and development of CHD.