Hippo-YAP信号通路为靶点的肿瘤治疗研究进展

Research progress on cancer treatment targeting the Hippo-YAP signaling pathway

Hippo通路是一个可调控细胞增殖和凋亡的信号转导通路,YAP(Yes-associated protein)为其主要效应分子。YAP为一个候选致癌因子,Hippo-YAP通路的异常与多种肿瘤的发生、发展密切相关。因此,以Hippo-YAP通路为靶点的治疗策略可能为肿瘤治疗提供新思路。一些可调控Hippo-YAP通路活性的药物/化合物如维替泊芬,可抑制肿瘤的发生或生长。本文主要对Hippo-YAP信号通路为靶点的肿瘤治疗研究进展进行综述。

Hippo pathway is a signaling network involved in the regulation of cell proliferation and apoptosis, whereas Yes-asso-ciated protein （YAP） is the major effector of the pathway. YAP is a candidate oncogene, and dysregulation of the Hippo-YAP pathway is closely related to the occurrence and progression of various tumors. Therefore, Hippo-YAP may provide a novel therapeutic target for cancer treatment. Some drugs or compounds that regulate the Hippo-YAP pathway activity, such as verteporfin, can inhibit the occurrence or growth of tumors. This review mainly focuses on the progress of studies on the use of Hippo-YAP signaling pathway as a target of cancer treatment strategies.