FOXL2在正常宫颈及宫颈癌组织中的表达及临床意义

Expression of FOXL2 in normal cervix and cervical cancer tissues and its clinical significance

目的研究转录因子FOXL2在正常宫颈组织及宫颈癌组织中的表达,探讨其在宫颈癌中的临床意义。方法免疫组化法检测10例正常宫颈和18例宫颈癌组织(10例Ⅰ期,8例Ⅱ+Ⅲ期)中FOXL2的表达情况,分析比较其表达与临床特征的关系。结果 FOXL2在正常宫颈组织中表达为0,在18例宫颈癌组织FOXL2阳性表达率为72.2%(13/18),其中宫颈癌I期阳性表达率50%,Ⅱ期及Ⅲ期阳性表达率为100%。FOXL2表达与宫颈癌临床分期、病理分级相关(P<0.05),而与宫颈癌患者的年龄无明显相关(P>0.05)。结论 FOXL2表达水平与宫颈癌恶性度呈正相关,且随着宫颈病变进展,FOXL2的阳性表达率呈递增趋势。

Objective To explore the expression of FOXL2 in normal cervix and cervical cancer tissues and its clinical significance. Methods Immunohistochemical method was used in examining FOXL2 expressions in 10 normal cervical tissue specimens and 18 cervical cancer tissues specimens （including 10 cases of stage Ⅰ, 8 of stage Ⅱ ＋ Ⅲ ）. The relationship between the expression and the clinical features were analyzed. Results FOXL2 expression was negative in normal cervical tissues, and positive rate was 72. 22 % （13/18） in cervical cancer specimens （50 % in stage Ⅰ and 100 % in stage Ⅱ and Ⅲ ）. FOXL2 expression was significantly correlated with the cervical cancer clinical stage and pathological grading （P 〈 0. 05 ）, while was not correlated with the age（P 〉 0. 05）. Conclusion The expression level of FOXL2 as well as positive rate of FOXL2 are positively associated with the evolution of cervical cancer malignant degree.