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大气颗粒物与DNA甲基化关系的研究进展

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摘要 大气颗粒物不断地危害着人类健康,它不仅与呼吸系统疾病、心血管疾病具有关联性,而且还可以诱导氧化应激、免疫缺陷和慢性炎症等与致癌作用至关重要的生物变化,而这些生物变化可以通过改变甲基化机制影响基因表达。在应对环境压力时,特定位点的DNA甲基化可以发生快速改变。
作者 赵永东 王菲菲 贾玉巧
机构地区 包头医学院公共卫生学院 中国环境科学研究院环境基准与风险评估国家重点实验室
出处 《毒理学杂志》 CAS CSCD 北大核心 2015年第4期305-309,共5页 Journal of Toxicology
基金 中国环境科学研究院中央级公益性科研院所基本科研业务专项(2009KYYW05)
关键词 大气颗粒物 DNA甲基化 全基因 定点基因
分类号 R99 [医药卫生—毒理学]
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参考文献30

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毒理学杂志
2015年 第4期

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