8-异前列腺F2a、KL-6、SP—D、瘦素在睡眠呼吸暂低通气综合征疾病中的研究进展

The research progress of 8-isoprostane F2a, KL-6, SP-D, leptin in patients with obstructive sleep apnea hypopnea syndrome

8-异前列腺F2a在体内生成结构稳定，不受食物脂质含量的影响，特异性强，能灵敏地反映体内氧化应激水平并与疾病严重程度相关，是评价氧化应激和脂质过氧化反应的理想生物指标。Ⅱ型肺泡细胞表面抗原6（KL-6）、肺表面活性蛋白D（SP—D）主要由肺泡Ⅱ型上皮细胞分泌，夜间慢性间断缺氧及再氧合损伤肺泡屏障、致肺泡部位内皮细胞氧化应激损伤、导致上皮细胞渗透性增高，使KL-6、SP—D浓度升高。肥胖是导致0SAHS的重要危险因素，瘦素是一种由脂肪细胞分泌的重要的抗肥胖激素。现对细胞因子8-异前列腺F2a、KL-6、SP—D、瘦素等生物标记物在OSAHS中的关系做一综述。

8-isoprostane F2a in body can generate a stable structure material which is not affected by dietary lipid content and strong specificity, can sensitively reflect the oxidative stress levels and is correlated with serious degree of disease,is the ideal evaluation biological indicators of oxidative stress and lipid peroxidation. KL-6 and SP-D are mainly secreted by alveolar type II epithelial ceils, at night, chronic intermittent hypoxia and reoxygenation injury alveolar barrier, the oxidative stress injury of endothelial cells in the alveolar region, resulting in increasing permeability of epithelial ceils, increased the concentration of SP-D and KL-6. Obesity is an important risk factor for OSAHS, and leptin is an important anti-obesity hormone secreted by fat cells. In this paper, the relationship between the biological indicators 8-isoprostane F2a,KL-6, SP-D, leptin and OSAHS are reviewed.