摘要
NLRX1是一类保守的胞浆模式识别受体，其分布广泛，主要定位于线粒体，结构上与NLRs家族的其他成员略有不同，表现为氮端为39个氨基酸构成的MT序列而非CARD结构域。NLRX1功能复杂，可以通过识别内外源性危险信号，触发相应的信号转导通路，实现对免疫炎症反应、ROS生成、线粒体损伤、自噬、凋亡的调节。研究表明，NLRX1与多种疾病的发生发展密切相关，对于其作用机制的研究，将给有效治疗包括肿瘤、自身免疫性疾病在内的许多疾病带来新的希望。
Nucleotide-binding domain and lcucine-rich-repeat-containing family member X1 （ NLRXI ） is a conserved cytoplasmic pattern recognition receptor, which is expressed ubiquitously. Its structure is slightly different from that of other nncleotide-binding domain （NBD）- and leucine-rich-repeat （LRR）-containing family （NLRs） members, mainly at the N-terminal that consists of a 39 amino acid-MT sequence rather than the CARD domain. NLRX1 is the first member that is constitutively localized in mitochondria. The function of NLRX1 is complicated. NLRX1 can be activated by outer invasive or inner dangerous signals,which,in turn,involves in the regulation of a broad spectrum of pathophysiological processes, including immune-inflammation responses, production of ROS, damage of mitochondria, autophagy, and apoptosis. Researches reveal that NLRX1 also closely related to the formation and development of many diseases. The study of the mechanisms underlying the action of NLRX1 may bring new hope for the effective therapy of many diseases including tumor and self-immune dysfunctions.
出处
《国际免疫学杂志》
CAS
2015年第5期440-444,共5页
International Journal of Immunology
基金
国家973计划（2014CB541702
2014CB541703）
国家自然科学基金（81570918
81072200）
