活性氮对免疫细胞的调控作用

The role of reactive nitrogen on the regulation of immune cells

活性氮（RNS）是体内活跃的活性分子，随着研究的深入，人们对其看法正在改变。越来越多的报道证明，RNS在机体的免疫调剂中发挥重要功能。RNS一方面可作为信号分子参与固有免疫的调节，包括对中性粒细胞的趋化、黏附和杀伤活性调节，还包括对NK细胞的活性及数量的调节；另一方面从调节树突状细胞（DCs）分化、抗原呈递及淋巴细胞的活化来调节适应性免疫。

Reactive nitrogen species （RNS） are a group of highly reactive chemicals in vivo. A number of studies have indicated that RNS are essential for immune response. On one hand, RNS can participate in the regulation of innate immunity as signal molecules, which regulate the functions of polymorphonuclear neutrophils （ PMNs）, such as chemotaxis, adhesion and PMNs - mediated killing of bacteria. RNS can also regulate the ac- tivity and quantity of natural killer cells （NKs）. On the other hand, RNS can modulate acquired immunity by regulating dendritic cells （DCs） differentiation, antigen presentation, and lymphocyte activation.