叉头盒蛋白A1在乳腺癌的作用

Research advances on the significance of FOXA1 in breast cancer Luo Xiangrong,

又头盒蛋白A1（FOXA1）基因在人体许多组织如乳腺、肝、胰腺、膀胱、前列腺、结肠、卵巢、肺和食管中表达，其表达与这些器官的发育及这些器官的肿瘤发生密切相关。目前研究发现其在调节细胞增殖、分化、发育及肿瘤形成、上皮间质转化（EMT）等过程中起重要作用，其表达与与ER、PR呈正相关，是乳腺癌良好预后的重要预测因子之一。

Forkhead box A1 （FOXA1） is expressed in various organs, including breast, liver, pancreas, bladder, prostate, colon, ovary, lung and esophagus. The FOXA1 expression is associated with the growth and carcinogenesis of these organs. It is recently demonstrated FOXA1 plays a significant role in diffe- rent biological processes including cell proliferation, differentiation, devolopment, carcinogenesis and the process of epithelial-mesenchymal transition （EMT） etc. Its expression is positively correlated with ER and PR expres- sion, and it is demonstrate to be one of the most important favorate prognostic factors of breast cancer.