1-磷酸鞘胺醇与胰岛素抵抗

Sphingosine-1-phosphate and insulin resistance

1-磷酸鞘胺醇（S1P）是神经酰胺代谢产生的一种生物活性脂质.它不仅是细胞外介质,也是细胞内第二信使,参与细胞的增殖、分化等生理过程.S1P与不同的受体结合产生的作用各异.研究表明其可以通过不同的途径参与胰岛素信号的调节,对胰岛素信号产生不同的影响,与肝脏、骨骼肌、胰岛等组织胰岛素抵抗的发生密切相关.

Sphingosine-1-phosphate（S1P） is a bioactive lipid metabolite of ceramide.It is not only the extracellular mediator,but also the intracellular second messenger involved in cell proliferation,differentiation,and other physiological processes.S1P has various effects when combining to different receptors.Studies have showed that it plays a role in insulin signaling regulation by diverse ways resulting in different influence.It is closely correlated with insulin resistance in liver,skeletal muscle,islet and so on.