活血清肠方对溃疡性结肠炎的临床研究

Clinical Research of Ulcerative Colitis Treated with Huoxue Qingchang Formula

目的探讨活血清肠方对溃疡性结肠炎(ulcerative colitis,UC)患者症状和血瘀证积分值的疗效、血液流变学变化及安全性。方法选择80例溃疡性结肠炎患者,随机分为治疗组40例,对照组40例;治疗组给予活血清肠方联合美沙拉嗪肠溶片口服治疗,对照组单用美沙拉嗪肠溶片剂,以4周为1个疗程,两个疗程后统计其总有效率,并对比分析两组患者治疗前后血液流变学各项指标和血瘀证积分值的变化。结果治疗组总有效率(92.5%,37/40)明显高于对照组(67.5%,28/40),血液流变学各项指标和血瘀证积分值较治疗前显著下降(P<0.05),且明显优于对照组(P<0.05)。结论活血清肠方不仅能改善UC患者的症状,降低血瘀证积分值,改善血液流变学异常,改善血液高黏滞综合征,而且安全性高;同时提出判断UC病情和预后的新指标,提出防治UC的新治则和新方剂。

Objective To explore the efficacy,hemodynamic changes and safety in treatment of the symptom and blood stagnation syndrome of ulcerative colitis（ UC） with huoxue qingchang formula. Methods Eighty patients of UC were randomized into a treatment group（ 40 cases） and a control group（ 40 cases）. In the treatment group,huoxue qingchang formula and mesalazin enteric- coated tablets were prescribed for oral administration. In the control,only mesalazin enteric- coated tablets were prescribed. The treatment for 4weeks made one session. Two sessions later,the total effective rate was calculated. The hemodynamic indexes and the value of blood stagnation syndrome were compared and analyzed in the patients of the two groups before and after treatment. Results The total effective rate（ 92. 5%,37 /40） in the treatment group was obviously higher than that（ 67. 5%,28 /40） in the control group. The hemodynamic indexes and the value of blood stagnation syndrome were reduced significantly as compared with those before treatment（ P〈 0. 05）,superior obviously as compared with the control group（ P 〈0. 05）. Conclusion Huoxue qingchang formula relieves UC symptoms,reduces the value of blood stagnation syndrome and improves in hemodynamic indexes and blood high viscosity syndrome but also presents the high safety. This therapy provides the new indexes for the judgment of UC condition and prognosis,and the prevention from the new pattern of UC,the new treating principle and formulas.