苇茎汤治疗慢性阻塞性肺疾病临床疗效的Meta分析

Meta Analysis of the Clinical Efficacy on Chronic Obstructive Pulmonary Disease with Weijin Tang

目的系统评价苇茎汤治疗慢性阻塞性肺疾病(COPD)的疗效及安全性。方法电子检索中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、中文科技期刊全文数据库(VIP)、万方数据库(Wanfang Data)等。收集已发表的关于苇茎汤治疗COPD的临床随机对照试验,根据Meta分析的要求对检索到的原始研究进行质量评估,采用Rev Man5.2对符合条件的文献进行Meta分析。结果共纳入15个随机对照试验,包括1027例患者。纳入研究的方法学质量较低,未发现苇茎汤与安慰剂对照的RCT研究。研究发现苇茎汤在改善COPD咳痰喘等症状及肺功能和血气分析指标方面与单存西医对症治疗相比,具有明显优势,所纳入的研究未见严重不良反应。结论目前苇茎汤治疗COPD的疗效证据有限,尚缺乏高质量的研究以增加证据强度。

Objective To evaluate systematically the efficacy and safety of weijin tang in treatment of chronic obstructive pulmonary disease（COPD）. Methods CBM,CNKI,VIP and Wanfang Data were used to collect the published clinical randomized controlled trials（RCTs）on the treatment of COPD with weijin tang. According to the requirement of Meta analysis,the original study was retrieved for the quality assess-ment. RevMan 5. 2 was used to have Meta analysis on the enrolled literatures. Results Totally,15 RCTs were included with 1027 cases involved. The quality of methodology in the included studies was low and the RCT was not found in comparison of weijin tang and placebo. It was discovered in the studies that weijin tang presented the apparent advantages in the relief of cough and asthma in COPD and improvements of lung func-tion as well as the indexes of blood - gas analysis as compared with the symptomatic treatment with simple western medicine. The severe adverse reactions had not been found in the included studies. Conclusion At present,the efficacy evidence of weijin tang is limited for the treatment of COPD. The high - quality study is still required so as to enhance the evidence intensity.