比较中药祛湿霜和丁酸氢化可的松乳膏治疗儿童湿疹的临床疗效

Comparison of the Clinical Efficacy on Children Eczema between Chinese Medicine Qushi Cream and Hydrocortisone Butyrate

目的比较中药祛湿霜和丁酸氢化可的松乳膏治疗儿童湿疹的疗效和安全性。方法根据随机数据表法,收回有效病例96例,其中祛湿霜组(A组)51例,丁酸氢化可的松乳膏组(B组)45例,两组均局部涂药,每日2次;治疗后3 d、7 d和14 d,根据湿疹皮损EASI评分评判疗效,根据不良事件发生率分析其安全性。结果两组皮损EASI评分随着疗程的增加逐渐降低,表明两组疗法治疗湿疹均有效,并随疗程增加,EASI积分改善也相应下降;在治疗后3 d、7 d和14 d,两组皮损EASI积分相应时间段比较差异无统计学意义(P>0.05),表明两组对皮损EASI积分改善相似。在治疗3d、7 d和14 d,B组的有效率均优于A组,但差异无统计学意义(P>0.05),表明两组的疗效相似。两组不良事件发生率比较差异无统计学意义(P>0.05),表明A组与B组的不良事件发生率相似。结论中药祛湿霜是治疗儿童湿疹的安全有效方法。

Objective To compare the efficacy and safety in the treatment of children eczema between Chinese Medicine qushi cream and hydroeortisone butyrate. Methods According to the random data table method,96 effective cases were collected,in which,51 cases were in a qushi cream group（ A group）and 45 cases in a hydrocortisone butyrate group（ B group）. The medicines were applied externally to the affected areas in the two groups,twice a day. In 3,7 and 14 days after treatment,according to the skin lesion,EASI score was used to determine the efficacy, According to the incidence of adverse events, the safety of treatment was analyzed. Results EASI scores of skin lesions were reduced gradually in the treatment of the two groups,indicating the effectiveness on eczema by the therapies in the two groups. The effectiveness was increased and EASI scores were declined along with the treatments. In 3,7 and 14 days after treatment, the differences in EASI score were not significant in the corresponding time phases in the two groups（ P 〉 0, 05 ）, indicating the similarity of the improvements between the two groups. The effective rates in 3,7 and 14 days of treatment in the B group were better than those in the A group, but without significant differences （ P 〉 0.05 ） ,indicating the efficacy similarity of the two groups. The difference in the adverse events was not significant between the two groups（ P 〉 0.05 ）, indicating the similarity of the incidence of the adverse events between the A and B groups. Conclusion Chinese medicine qushi cream is safe and effective in treatment of children eczema.