疏风解毒胶囊治疗慢性鼻窦炎不伴鼻息肉的临床观察

Clinical Observation of Chronic Rhinosinusitis without Nasal Polyps Treated with Shufeng Jiedu Capsules

目的观察疏风解毒胶囊治疗慢性鼻窦炎不伴鼻息肉(chronic rhinosinusitis without nasal polyps,CRSs NP)的临床疗效。方法将门诊100例CRSs NP患者按就诊时间随机分成治疗组与对照组。对照组予克拉霉素口服、丙酸氟替卡松喷鼻、桃金娘油胶囊口服、鼻腔冲洗等治疗,治疗组在对照组治疗基础上加用疏风解毒胶囊口服,4粒/次,3次/d。疗程3个月。观察两组患者治疗前后主要症状、体征变化,并评定患者临床治疗效果、不良反应发生情况。结果经3个月治疗后,两组治疗均能显著改善患者预后(P<0.05),但治疗组VAS临床症状评分、Lund-Kennedy评分、SNOT-20条评分明显低于对照组(P<0.05),治疗组总有效率明显高于对照组(P<0.05)。两组均未见严重不良反应发生。结论疏风解毒胶囊能够提高CRSs NP临床治疗效果,改善患者生活质量。

Objective To observe the clinical efficacy on chronic rhinosinusitis（CRS）without nasal polyps treated with shufeng jiedu capsules. Methods One hundred outpatients of CRS without nasal polyps were randomized into a treatment group and a control group according to the visit sequence. In the control group,clarithromycin for oral administration,fluticasone propionate nasal spray,myrtol caspules for oral ad-ministration and nasal rinsing were applied. In the treatment group,on the basis of the treatment as the control group,shufeng jiedu capsules for oral administration was supplemented,4 capsules each time,three times a day. The duration of treatment was 3 months. The changes in the main symptoms and physical signs were ob-served before and after treatment in the patients of the two groups. The clinical efficacy and adverse reactions were evaluated. Results After 3 months treatment,the prognosis was significantly improved in the patients of either group（P ﹤ 0. 05）. VAS,clinical symptom score,Lund - Kennedy score and SNOT - 20 score in the treatment group were lower obviously than those in the control group（P ﹤ 0. 05）. The total effective rate in the treatment group was higher apparently than that in the control group（P ﹤ 0. 05）. The severe adverse reac-tion was not found in the two groups. Conclusion Shufeng jiedu capsules improve the clinical therapeutic effect and the quality of life in the patients of CRS without nasal polyps.