强力益气方治疗重症肌无力的疗效及声学评价

Efficacy of Qiangli Yiqi Formula on Myasthenia Gravis and Acoustic Evaluation

目的研究强力益气方治疗重症肌无力(Myasthenia gravis,MG)的疗效及计算机声学评价。方法将80例脾气虚型重症肌无力(MG)患者,分为MG构音障碍组40例,MG非构音障碍组40例,每组又分为男女两小组,每小组20例。均采用强力益气方加减治疗,疗程6周。另设健康嗓音对照组男女各20例。治疗前后分别选用绝对评分量表、脾气虚型中医症候量表、计算机声学检测包括基频微扰(jitter)、振幅微扰(shimmer)、F0标准差和标准声门噪声能量(NNE),对疗效进行量化比较及疗效评定。结果构音障碍组总有效率85.00%,与治疗前比较,F0标准差、shimmer和NNE值均降低,差异有统计学意义(P<0.05,P<0.01)。非构音障碍组总有效率95.00%。声学检测无明显变化。结论强力益气方治疗MG构音障碍患者疗效确切。声学评定方法用于评价重症肌无力构音障碍的诊断和疗效评价具有临床意义。

Objective To study the efficacy of qiangli yiqi formula on myasthenia gravis （MG）and computer acoustic evaluation. Methods Eighty patients of MG of spleen qi deficiency type were divided into a dysarthria group（40 cases）and a non -dysarthria group（40 cases）. Each group was subdivided into a male group and a female group ,20 cases in each one. The modified qiangli yiqi formula was adopted and the dura- tion of treatment was 6 weeks. Additionally, the healthy voice control subgroups were set up, for males and fe- males separately ,20 cases in each one. The absolute score scale,TCM spleen deficiency scale and computer acoustic detection including jitter, shimmer, F0 SD and NNE were selected for the quantitative comparison of efficacy and efficacy assessment before and after treatment separately. Results The total effective rate was 85.00% in the dysarthria group. The differences in F0 SD, shimmer and NNE were significant as compared with those before treatment （P 〈 0.05, P 〈 0.01 ）. The total effective rate was 95.00% in the non - dysarthria group. The difference in acoustic detection was not apparent. Conclusion Qiangli yiqi formula achieves the definite efficacy on dysarthria in MG patients. The acoustic evaluation method is significant clinically in the diagnosis and efficacy evaluation on MG dysarthria.