转移相关因子-3在宫颈癌浸润转移中的相关性研究

Study on the correlation between metastasis-associated factor-3 and invasion and metastasis of cervical cancer

目的研究转移相关因子-3(MTA3)及E-cadherin蛋白在宫颈癌中的表达,并分析两者间的相关性。方法利用免疫组化染色SABC法检测85例人体宫颈癌标本中MTA3和E-cadherin蛋白的表达。结果低分化宫颈鳞状细胞癌和高分化宫颈鳞状细胞癌中MTA3和E-cadherin的阳性表达率分别为21.74%、68.97%和30.43%、62.07%,差异有统计学意义(P<0.05)。宫颈癌临床分期Ⅱa1组和Ⅰa组中MTA3及E-cadherin的阳性表达率分别为27.78%、72.72%和27.78%、60.60%,差异有统计学意义(P<0.05)。有淋巴结转移组和无淋巴结转移组中MTA3及E-cadherin的阳性表达率分别为25.92%、58.62%和33.33%、53.45%,差异有统计学意义(P<0.05)。结论 MTA3表达缺失常伴随E-cadherin表达减少,提示MTA3是宫颈癌晚期和淋巴转移的重要因子。

Objective To explore the expressions of metastasis- associated factor- 3（ MTA3） and E- cadherin protein in cervical cancer,analyze the correlation. Methods Immunohistochemical SABC method was used to detect the expressions of MTA3 and E- cadherin in 85 cases with cervical cancer. Results The positive expression rates of MTA3 and E- cadherin in poorly- differentiated cervical squamous cell carcinoma and highly- differentiated cervical squamous cell carcinoma were 21. 74%,68. 97% and 30. 43%,62. 07%,respectively,there were statistically significant differences（ P 〈0. 05）. The positive expression rates of MTA3 and E- cadherin in Ⅱa1 group and Ⅰa group were 27. 78%,72. 72% and 27. 78%,60. 60%,respectively,there were statistically significant differences（ P 〈0. 05）. The positive expression rates of MTA3 and E- cadherin in cases with lymph node metastasis and cases without lymph node metastasis were25. 92%,58. 62% and 33. 33%,53. 45%,respectively,there were statistically significant differences（ P 〈0. 05）. Conclusion MTA3 expression deletion is frequently associated with low expression of E- cadherin,which indicates that MTA3 is an important factor in advanced cervical cancer and lymph node metastasis of cervical cancer.