聚乙二醇干扰素α-2a治疗慢性丙型肝炎疗效观察

Analysis of pegylated interferon alpha-2a efficacy in the treatment of chronic hepatitis C

目的：探讨聚乙二醇干扰素α-2a（PEG-IFN-α-2a）治疗慢性丙型肝炎的临床疗效和安全性。方法选择170例慢性丙型肝炎患者作为研究对象，采用数字表法随机分为两组，观察组85例采用PEG-IFN-α-2a治疗，对照组85例采用普通干扰素α-2b治疗，比较两组患者的临床疗效及安全性。结果观察组治疗12周、24周以及24周丙氨酸氨基转移酶（ALT）好转率分别为70．59％、80．00％、92．94％，高于对照组的52．94％、62．35％、70．58％（χ2＝5．42、6．71、4．83，均P＜0．05）；观察组治疗12周、24周以及24周HCV-RNA转阴率分别为64．71％、75．29％、91．76％，均明显高于对照组的50．59％、61．18％、70．59％（χ2＝4．28、7．68、6．31，均P＜0．05）；两组不良反应发生率差异无统计学意义。结论 PEG-IFN-α-2a治疗慢性丙型肝炎具有十分显著的疗效，优于普通干扰素α-2b，值得临床广泛推广和应用。

 Objective To investigate the clinical efficacy and safety of the pegylated interferon alpha-2a （PEG-IFN-a-2a）in treatment of chronic hepatitis C.Methods 170 cases of patients with chronic hepatitis C were included in the study,by using digital table method they were randomly divided into two groups,the observation group of 85 cases were treated with PEG-IFN-alpha-2a therapy,and 85 cases in the control group using ordinary interferon alpha-2b therapy.Curative effect and safety of two groups of patients were compared.Results The obser-vation group treated for 12 weeks,24 weeks and 24 weeks of alanine aminotransferase （ALT）and improvement rate were respectively 70.59%,80%,92.94%,which were higher than that of the control group （52.94%,62.35% and 70.58%）（χ2 =5.42,6.71,4.83,all P〈0.05）.The observation group for 12 weeks,24 weeks and 24 weeks of HCV-RNA negative rate were 64.71%,75.29%and 91.76%,obviously were higher than the control group of50.59%, 61.18% and 70.59% （χ2 =4.28,7.68,6.31,all P〈0.05）.Adverse reaction rates were not statistically signifi-cant.Conclusion The pegylated interferon alpha-2a （PEG-IFN-a-2a）in treatment of chronic hepatitis C has a significant curative effect of PEG-IFN-alpha-2a therapy in chronic hepatitis C,which is better than the ordinary interferon alpha-2b,and is worthy of extensive promotion and application.