羊口疮病毒活载体疫苗和生物制剂的研制现状

Research Status on the Development of Live Vector Vaccine and Biological Agents of Orf Virus

羊口疮病毒的基因组结构、编码基因复制特性及其在宿主和非宿主体内快速启动机体的免疫反应特点,使其具有作为活病毒疫苗载体的特殊优势。此外,该病毒自身及其编码蛋白的双向免疫调节功能使其具有作为临床使用生物制剂的巨大潜力。作者对基于羊口疮病毒的重组疫苗和生物制剂的研制现状进行了详细的综述,以期为该病毒的疫苗研制、生物制剂研发及临床应用提供参考。

Orf virus（ORFV）has special advantages as the live viral vaccination vectors due to its structure of genome,replication characteristics of encoding gene and quick activation of immunoreactions in host and non-host.In addition,ORFV and its coding proteins have huge potential as clinical biological agents for their function as dual immune modulators.Research statuses on recombinant vaccine of ORFV and biological agents were reviewed which would provide the reference for the development and clinical application of vaccination and biological agents.