家兔脑出血脑磁感应相位移与颅内压变化的相关性

Correlation between cerebral magnetic induction phase shift and intracranial pressure changes during the cerebral hemorrhage of rabbits

目的:前期的磁感应相位移(Magnetic Induction Phase Shift,MIPS)研究已经显示,颅内压(Intracranial pressure,ICP)作为一项参照指标,它与MIPS之间具有一定的基础相关性。本研究通过动物实验进一步分析急性脑出血下,MIPS与ICP变化之间的关系。方法:通过给兔子脑部注入3 m L^6 m L自体血诱发其急性脑出血。然后对兔子的脑出血模型进行由脑出血引起的MIPS和ICP变化的对比实验,分为实验组(7只)和对照组(4只)。实验中,研究者利用自制MIPS检测系统和ICP监护仪分别采集兔子脑出血过程中的MIPS和ICP信号,随后对采集得到的信号进行处理分析。最后,对MIPS与ICP的变化进行相关性分析。结果:实验组中MIPS随着血液注射量的增加而明显下降,ICP则随着血液注射量的增加呈现出先缓慢上升而后迅速上升的变化趋势。同时兔子的ICP和MIPS之间呈现出较大的负相关性。另外,所有实验样本中MIPS的斜率变化都表现出先迅速随后转向缓慢的趋势,恰与ICP的变化趋势相反。结论:MIPS在监测脑出血过程中具有良好的早期敏感性,且其变化与ICP的变化呈明显的负相关性,可见MIPS技术在监测脑出血和获取ICP信息方面具有较大的价值和潜力。

Objective The previous studies on magnetic induction phase shift （MIPS） has proved that the intracranial pressure （ICP）, as a reference index, is fundamentally related with MIPS to an extent. The correlation between MIPS and ICP during acute cerebral hemorrhage （ACH） is further analyzed by animal experiments. Methods ACH was induced by injecting 3 to 6 mL autotogous blood into the brain of rabbits, and then the models of cerebral hemorrhage were divided into experimental group （n=7） and control group （n=4） to do the MIPS and ICP changes comparative experiments. The signals of MIPS and ICP during ACH were respectively collected by the homemade MIPS detection system and the ICP monitor, and the collected signals needed to be processed. At last, MIPS and ICP changes were made correlation analysis. Results With the increase of injection volume in the experimental group, the MIPS decreased significantly, while ICP slowly increase at first and then rapidly increase. A high negative correlation was observed between the changes of ICP and MIPS of rabbits from experimental group. The MIPS slopes of all experimental samples presented a trend from fastness to slowness, with a reverse of the change of ICE Conclusion The MIPS has a good early sensitivity and present a high negative correlation with ICP changes during ACH. The MIPS method is valuable and potential for monitoring ACH and obtaining the ICP information.