胰岛素强化治疗妊娠期糖尿病35例

Clinical Observation of Insulin Intensive Treatment for 35 Cases of Gestational Diabetes Mellitus

目的:探讨胰岛素强化治疗方案对妊娠期糖尿病(GDM)患者及胎儿的影响。方法:将70例妊娠期糖尿病患者按照随机数字表法分为2组,其中对照组35例用预混人胰岛素类进行常规治疗;观察组35例每天速效胰岛素3次注射加基础胰岛素1次注射进行强化治疗;对比分析两组患者治疗后血糖控制水平、胰岛素抵抗(HOMA-IR)程度、胰岛素分泌指数(HOMA-β)变化、妊娠合并症及新生儿合并症的发生率等。结果:观察组的患者血糖控制效果更佳,显著降低母婴并发症(P<0.01),胰岛素抵抗程度与胰岛素分泌功能均有所改善(P<0.05)。结论:胰岛素强化治疗妊娠期糖尿病可以减少母婴并发症的同时,可以在一定程度上改善患者的胰岛功能水平。

Objective： To investigate the effect of intensive insulin therapy on patients with gestational diabetes mellitus（ GDM）. Methods： 70 cases of pregnancy with gestational diabetes were divided into 2 groups according to the random number table. The control group（ n = 35） pre mixed insulin class conventional therapy; observation group（ 35 cases） every available insulin three times injection plus basal insulin 1 injection intensive treatment; after treatment,the patients in the two groups compared with control of blood glucose levels,insulin resistance（ HOMA- IR）,insulin secretion index（ HOMA- β） changes,pregnancy complications and neonatal complications occurrence rate. Results： in the observation group,the patients blood glucose control effect is better,significantly reduce the complications of mothers and infants（P〈0. 01）,the degree of insulin resistance and insulin secretion were somewhat improved（P〈0. 05）. Conclusion： insulin intensive treatment of gestational diabetes can reduce maternal and infant complications at the same time,to a certain extent,improve the level of pancreatic islet function.