环糊精及其衍生物在中药提取中的应用研究进展

Research progress in applications of cyclodextrin and its derivatives in Chinese materia medica extracting

目前我国中药提取多采用有机溶剂加热、回流等方法,成本高、提取效率低,且多数有机溶剂具有毒性,存在安全隐患。环糊精及其衍生物因具有优良的生物学特性和独特的理化性质,日益受到人们的关注,将其直接应用于中药和植物药活性成分提取,进而提高天然药物制剂水平成为研究的热点。从常用的辅助提取方法、选择性提取以及提取中药活性成分的应用等方面综述环糊精及其衍生物的研究进展,以期为中药、植物药制剂技术的发展提供思路与方法。

At present, heat or reflux extraction with organic solvents is widely used in the production of herb extracts in China with high cost and low extraction efficiency. Moreover, toxic organic solvents could increase the probability of safety risks in production. Cyclodextrin（CD） and its derivatives are getting more and more attention of people, because of their excellent biological characteristics and unique properties. Recently it becomes a hot research about the direct application of CD in Chinese materia medica（CMM） extracting. So in this paper, the research of the application of CD in CMM extracting was reviewed from the aspects of extraction method, selective extraction, and the application of CD in the extraction of active ingredients in CMM, so as to provide the new guidance for the application of CD and its derivatives in the field of CMM.