摘要
地黄Rehmannia glutinosa为玄参科地黄属植物,其块根为常用中药。该植物块根和叶中含有大量的环烯醚萜类成分,同时还存在紫罗兰酮、二苯乙烯、三萜、黄酮、酚酸、木脂素、含氮类、糖及其他类化合物;药理研究表明梓醇等多个成分具有抗心脑血管疾病、神经保护、抗糖尿病及其并发症、抗骨质疏松、增强免疫等多种药理作用。由于中药地黄显著的滋补作用,历来是研究的热点。对最近5年有关地黄的化学成分和药理研究进行综述,为进一步研究提供参考。
Rehmannia glutinosa, belonging to Scrophulariaceae family, is widely distributed in China, and its root tubers are commonly called "Dihuang" in Chinese. So far large quantity of unique iridoids have been isolated from the plant, together with other types of active principles, such as megastigmas, phenethyl alcohols, triterpenes, flavonoids, lignans, alkaloids, phenolic acids, and sugars. The plant has the significant effects on cardiovascular diseases, neuroprotection, diabetes and its complications, osteoporosis, and hyperlipemia, and the active principles have entitled the plant to serve several different bioactivities including neuroprotective, hypoglycemic, lipid-lowering, anti-oxidant, antifatigue, and immuno-regulation effects. This paper reviews in detail the categorization of chemical constituents from R. glutinosa and their pharmacological activities.
出处
《药物评价研究》
CAS
2015年第2期218-228,共11页
Drug Evaluation Research
基金
国家自然科学基金-河南联合基金(U1304824)
河南中医学院博士科研基金(BSJJ2012-04)
关键词
地黄
环烯醚萜
梓醇
抗心脑血管疾病
神经保护
降血糖
Rehmannia glutinosa Libosch.
iridoid
catalpol
cardiovascular and cerebrovascular diseases
neuroprotective
hypoglycemic