儿童及青少年1型糖尿病患儿生存质量分析

Quality of life in children and adolescents with type 1 diabetes

目的了解儿童及青少年1型糖尿病患者生存质量,探讨其影响因素。方法收集住院的儿童及青少年1型糖尿病患儿38例,分为血糖控制良好组(21例)和血糖控制不佳组(17例),采用儿童生存质量测定量表(PedsQL4.0)进行问卷调查,对数据进行分析,评价患儿的生命质量,并采用Pearson相关对影响患儿生命质量的因素进行多元线性逐步回归分析。结果血糖控制不佳组患儿的生理功能、心理社会功能、生存质量总分较血糖控制良好组低,两组比较差异均有统计学意义(均P<0.05)。患儿的生存质量与空腹血糖(FPG)、糖化血红蛋白(HbA_1c)、餐后2h血糖(2hPG)、糖类抗原19-9(CA19-9)、血清β羟丁酸呈负相关(P<0.05或0.01),FPG、血清β羟丁酸为最相关影响因素(P<0.05或0.01)。结论加强血糖控制,积极预防糖尿病酮症发生,监测CA19-9变化,有利于改善儿童及青少年1型糖尿病患儿生存质量。

Objective To investigate the quality of life in children and adolescents with type 1 diabetes. Methods Pediatric Quality of Life Inventory Measurement Models（PedsQL40） was applied to investigate the quality of life in 38 children and adolescents with type 1 diabetes. Pearson correlation and regression was used to analyze the relevant factors affecting the quality of life, Results Partial correlation analysis showed that quality of life was negatively correlated with FPG, HbAlc, 2hPG, serum CA199 and 13 -hydroxybutyrate（P〈0.05）. Stepwise multiple regression analysis showed that FPG and serum 13 -hydroxybutyrate were the most relevant factors. Conclusion Intensive blood sugar control and prevention of diabetic ketoacidosis may improve the quality of life in children and adolescents with type 1 diabetes.