硫化氢在结直肠肿瘤中的作用及机制

Hydrogen sulfide and its research progress in colorectal cancer

硫化氢（H2S）作为新发现的第3种气体信号分子，在胃肠道系统等多种病理生理过程中发挥着重要作用。最近研究发现H2S可能通过Sirtuin type1（SIRT1）途径或Ras／mitogen activated protein kinase（Ras／MAPK）信号通路等机制影响结直肠肿瘤细胞的增殖、转移和分化；也可通过抑制细胞自噬和细胞凋亡等途径促进结直肠肿瘤的发生；还可能通过激活ERK、p38-MAPK的磷酸化抑制肿瘤细胞（WiDr）的增殖。本文对胃肠道组织中H2S的生成与代谢及其在结直肠肿瘤中的作用及机制研究作一综述。

Hydrogen sulfide （H2 S）, which is as the third newly discovered gaseous signal molecule, plays an important physiological and pathology role in the gastrointestinal system. The recent studies indicate that H2S can stimulate bioenergetics, cell proliferation, and angiogenesis in colon cancer, the mechanism of which may activate Sirtuin type 1 （ SIRT1 ） pathway or Ras/mitogen activated protein kinase mechanism（Ras/MAPK） signaling pathways. In addition to bioenergetie effects, endogenous H2 S may also contribute to tumor growth by additional mechanism including inhibition of autophagy and apoptosis pathway. Howewer, H2 S may stimulate the phosphorylation of extracellular signal-regulated kinase （ ERK ） and p38 mitogen-activated protein kinase（MAPK） to inhibit cancer cell growth. This paper reviewed the regulation of the production and metabolism of H2 S in the gastrointestinal tract and the possible action mechanisms on colorectal cancer.