无干眼症状儿童过敏性结膜炎中的泪膜稳定性研究

Tear film stability in allergic conjunctivitis children without symptoms of dry eye

目的观察无干眼症状的儿童过敏性结膜炎患者的泪膜稳定性。设计回顾性病例系列。研究对象无干眼症状的儿童季节性过敏性结膜炎患者30例（60眼）。无干眼症状的屈光不正患儿20例（40眼）为正常对照组。方法受试者进行病史询问以及外眼、眼前节及干眼相关检查,包括泪膜破裂时间（BUT）、基础泪液分泌试验（SIt）、角膜荧光素染色（FL）。荧光素染色评分0-12分,无染色为0分。主要指标BUT、SIt和FL评分。结果观察组与对照组BUT分别为（7.35±2.46）s、（11.95±2.183）s（t=9.569,P=0.000）;SIt分别为（18.28±5.123）mm、（16.50±5.149）mm（t=1.702,P=0.092）;FL评分不为0者分别为13例（20眼）、6例（6眼）（χ2=4.193,P=0.041）。观察组中FL评分、BUT与病史长短无显著相关性。结论无干眼症状的儿童季节性过敏性结膜炎患者也可能存在泪膜稳定性下降和角膜上皮完整性受损的改变。

Objective To study the relationship of children allergic conjunctivitis with symptoms of dry eye. Design Retrospective cases series. Participants 30 cases（60 eyes） of children seasonal allergic conjunctivitis, and 20 cases（40 eyes） of children ametropia as control group were analyzed. All of them had no symptoms of dry eye. Methods All subjects were inquired disease history and examined including external eyes, anterior segment, breakup time（BUT）, corneal fluorescein staining（FL） and Schirmer I test（SIt）. FL score was evaluated from 0 to 12, and 0 score indicated no staining of cornea. Main Outcome Measures BUT, SIt and FL score. Results BUT in allergic conjunctivitis group and in control group was（7.35±2.46）s,（11.95±2.183）s, respectively（ t =9.569,P=0.000）.SIt in allergic conjunctivitis group and in control group was（18.28±5.123） mm,（16.50±5.149） mm, respectively（ t=1.702,P=0.092）. The patient number of non 0 FL score in allergic conjunctivitis group and in control group was 13 cases（20 eyes）, 6 cases（6 eyes）, respectively（χ2=4.193, P=0.041）. There was no significant correlation between the time length of disease and FL score, BUT in allergic conjunctivitis group. Conclusion There was the correlation to dry eye in children seasonal allergic conjunctivitis even without symptom of dry eye. The decreased tear break-up time and positive fluorescent staining were the main representations.