经皮肾动脉去交感神经消融术治疗顽固性高血压疗效观察

Evaluate the effects of renal sympathetic denervation on patients with resistant hypertension

目的观察肾动脉去交感神经消融术治疗顽固性高血压患者术后6个月内的血压变化及用药情况,观察该手术对血压的影响。方法对比观察15名于本院行肾动脉去交感神经消融术患者术前及术后1、3、6个月血压变化,观察术后血压达标率;对比观察术前术后药物使用种类及并发症。结果患者术前及术后1、3、6个月收缩压分别为(164±14)mm Hg、(138±11)mm Hg、(138±8)mm Hg、(135±7)mm Hg;舒张压分别(98±10)mm Hg、(84±9)mm Hg、(83±7)mm Hg、(81±8)mm Hg;收缩压和舒张压术前与术后比较,差异均有统计学意义(P<0.05);术后1、3、6个月血压达标率分别为66.7%、80.0%、86.7%。患者服药种类由术前的(3.6±0.9)种降至术后的(2.4±0.8)种(P<0.05);所有患者均未发现近期及远期并发症。结论肾动脉去交感神经消融术治疗顽固性高血压有效、安全;术后降压效应有一定的时间延续性。

Objective To observe the blood pressure and drug using whithin 6 months of renal sympathetic denervation（RDN） on patients with resistant hypertension. Methods 15 patients with resistant hypertension after renal sympathetic denervation were observed.The the blood pressure（BP）, ratio of BP up to the standard,types of drug using and complications were observed before RDN and after RDN in 1, 3, 6months. Results The Systolic diastolic blood pressure before RDN and after RDN in 1, 3, 6months were （164±14）mmHg, （138±11）mmHg, （138±8） mmHg,（135±7）mm Hg（P 〈 0.05）, the diastolic blood pressure before RDN and after RDN in 1, 3, 6months were （98±10）mm Hg, （84±9）mm Hg, （83±7）mm Hg, （81±8）mm Hg（P〈0.05）.The ratio of BP up to the standard were 66.7%, 80.0%, 86.7%（P〈0.05）. The types of drug using were （3.6±0.9） kinds before RDN and decreased to （2.4±0.8） kinds after RDN（P〈0.05）.All patients had no complications. Conclusion RDN can be safety and effectively used in patients with resistant hypertension and the effects have Time continuity.