丙戊酸钠、西比灵治疗偏头痛86例疗效观察

The effective observation of sodium valproate and flunarizine in treatment of 86 cases with migraine

目的：研究分析丙戊酸钠与西比灵用于偏头痛的临床效果。方法选择2011年1月~2013年4月期间在我院接受治疗的86例偏头痛患者，通过抽签的方法将其分成对照组与观察组。对照组43例患者应用西比灵药物治疗，观察组43例患者在西比灵治疗的同时加用丙戊酸钠治疗。比较两组患者的临床疗效、头痛综合评分以及不良反应等并具体分析。结果观察组43例患者的总疗效率为93.02%（40/43）明显高于对照组的81.40%（35/43），差异有统计学意义（P＜0.05）。并且观察组患者的头痛综合评分为（10.6±4.9）分，明显低于对照组的（16.6±5.2）分，差异有统计学意义（P＜0.05）。观察组患者发生不良反应的机率为11.63%（5/43）相比对照组的9.30%（4/43），差异无统计学意义（P＞0.05）。结论丙戊酸钠联合西比灵治疗偏头痛能明显缓解患者的头痛症状，并且产生的不良反应较轻，临床的实用价值、推广价值较高。

Objective To study and analyze the clinical effect of sodium valproate and flunarizine in treatment of migraine. Methods 86 patients with migraine treated in our hospital from January 2011 to April 2013 were selected, which were divided into a control group and an observation group by using the method of drawing lots. The control group with 43 cases received sibelium, while the observation group with another 43 cases further received sodium valproate, the clinical efficacy, with headache scores and adverse reaction between the two groups after the therapy, were compared and analyzed. Results The total efficiency rate of the observation group was 93.02%（40/43）, was significantly higher than that in the ontrol group with 81.40% （35/43）. There was statistically significant difference （P〈0.05）. And, the comprehensive score of headache patients were （10.6±4.9）, which was significantly lower than that in the control group （16.6±5.2）. There was statistically significant difference（P〈0.05）. In addition, the incidence of adverse reaction in observation groups was 11.63%（5/43） was compared with control group, with 9.30%（4/43）. There was no statistically significant difference（P 〉 0.05）. Conclusion Using sodium valproate combined with flunarizine to treat migraine can relieve the symptoms of headache and reduce the adverse reactions, which has a high clinical practical value and popularization value.