甘草锌与喜炎平联用治疗小儿疱疹性口炎的临床观察

Clinical Observation on Treatment of Infantile Herpetic Stomatitis by Xiyanping Combined with Licorice Zinc

目的:探讨治疗小儿疱疹性口炎安全有效的治疗方案。方法:选择2011年7月至2014年7月三年间符合《实用儿科学》第七版疱疹性口炎的临床病例240例,随机分成治疗组和对照组。治疗组采用甘草锌与喜炎平联合治疗,对照组采用利巴韦林治疗,持续治疗3天。结果:两组在发病年龄、病程等方面均具有可比性(P>0.05),治疗组退热时间为(37.54±17.44)小时,与对照组(49.45±20.57)相比明显缩短,具有统计学意义(P<0.01);治疗组溃疡消退时间为(68.73±24.24)小时,与对照组(103.10±42.85)相比明显缩短,具有统计学意义(P<0.01)。治疗组显效率(81.67%)显著高于对照组(45.83%)。结论:喜炎平具有抗病毒、抗炎、清热解毒及增强细胞免疫作用,甘草锌是由甘草酸与锌结合制得的锌制剂,具有抗炎、促进皮肤黏膜愈合的作用。两药联合治疗小儿疱疹性口炎具有较好的临床疗效,为治疗小儿疱疹性口炎提供了一种安全、有效的治疗方案。

Objective： To investigate the treatment is safe and effective in children with herpetic stomatitis. Methods： Choose 240 cases which in accordance with the diagnostic criteria of herpetic stomatitis from 2011 July to 2014 July, were randomly divided into the treatment group and the control group. Treatment group was giving Licorice Zinc and Xiyanping, control group using the Ribavirin, continuous treatment for 3 days. Results： Two groups were comparable in age and course of disease（P〈0.05）. And the time until fever clearance was（37.54±17.44） hours in treatment group, but（49.45±20.57） hours in control group, Two groups were significant difference（P〈0.01）. Ulcer elapsed time of the treatment group was（68.73±24.24） hours, and control group was（103.10±42.85） hours. Two groups were significant difference（P〈0.01）. The significant efficiency of treatment group is 81.67%, and the control group was 45.83%. Conclusion： The pharmacological of Xiyanping was antiviral, anti-inflammatory, detoxification and enhances the cellular immune function. Licorice Zinc is composed of glycyrrhizin and zinc, the pharmacological actions was antiinflammatory, and promotes the skin mucous membrane healing. These two drugs in the treatment of children with herpetic steatites has better clinical curative effect, provides a safe, effective therapy for the treatment of children with herpetic stomatitis.