基于关联规则和复杂系统熵聚类的腰椎间盘突出症用药规律研究

Study on the Medication Law in Treatment of Lumbar Disc Protrusion Based on Association Rules and Complex System Entropy Cluster

通过中国知网、重庆维普、万方数据库收集近5年治疗腰椎间盘突出症文献中的中药处方,分析处方中各种药物的使用频次、药物之间的关联规则、核心药物组合,基于中医传承辅助平台(TCMISS)软件分析腰椎间盘突出症中药处方的用药规律。对筛选出的310个中药处方进行分析,确定处方中药物的使用频次、四气五味、归经、药物之间的关联规则,挖掘出16个核心组合。腰椎间盘突出症常用的药物以活血化瘀药、补血药、补阳药、补气药、祛风湿散寒药、发散风寒药、祛湿药为主,治法主要是活血化瘀、益气补阳补血、祛风湿散寒。药物四气的分布以温、平、凉为主,五味的分布以甘、苦、辛为主。药物归经的分布以肝、肾、脾为主。当归、牛膝、杜仲、甘草、桑寄生、独活、茯苓、川芎、续断、秦艽、地龙、白芍、桃仁、红花是临床治疗腰椎间盘突出症常用的核心药物。

The Chinese herbal formulas for the treatment of lumbar disc protrusion in recent 5 years were retrieved from CNKI,Chongqing VIP and Wanfang database. The use frequency of each medicine in the formulas,the association rules among medicines and the combination of core medicines were analyzed. Based on TCMISS software,the medication law of herbal medicines was analyzed for the treatment of lumbar disc protrusion. Three hundred and ten herbal medicine formulas were screened for analysis. The use frequency of medicines,the nature and flavor,meridian tropism and the association rules among medicines were deter-mined. Sixteen core combinations were explored. The common medicines for lumbar disc protrusion were acti-vating blood circulation,resolving stasis,tonifying qi,yang and blood,expelling wind,damp and cold. The na-tures of medicines were mainly warm,neutral and cold and the flavors were mainly sweat,bitter and pungent. The liver,kidney and spleen meridians were mainly involved. The core medicines in clinical treatment of lum-bar disc protrusion were angelica sinensis,radix achyranthis bidentatae,eucommia ulmoides,liquorice,para-sitic loranthus,radix angelicae pubescentis,poria cocos,ligusticum wallichii,radix dipsaci,fraxinus bun-geana,lumbricus,radix paeoniae alba,semen persicae and safflower carthamus.