SOX4和P53在120例胃癌组织中的表达及意义

Expressions and Significance of SOX4 and P53 in Gastric Cancer

[目的]研究SOX4及p53在胃癌组织中的表达,探讨其生物学行为在胃癌发生、发展中的作用。[方法]收集胃癌标本120例,另取30例同期胃镜检查无癌变病变患者的正常胃黏膜,并经病理证实无明显炎症改变的标本作为对照。采用免疫组化技术检测SOX4及p53表达情况,分析SOX4及p53表达与胃癌患者性别、年龄、分化程度、浸润深度等的关系。[结果 ]胃癌组织中SOX4及p53的表达率（51.7%和87.5%）显著高于对照组（0和3.3%）（P〈0.05）,SOX4在低分化胃癌、61~76岁年龄组和Ⅱ期的表达率显著高于高分化组、其他年龄段组和Ⅰa~Ⅰb期（P〈0.05）;p53的表达率在胃癌Ⅱ期和Ⅲa~Ⅳ期阳性表达率高于Ⅰa~Ⅰb期（P〈0.05）。胃癌组织中SOX4与p53表达未见相关性（r=2.30,P〉0.05）。[结论 ]胃癌组织中SXO4与p53表达上调,两者没有相关性;SXO4表达与胃癌发生发展相关。

[Purpose] To investigate the expressions of SOX4 and p53 in gastric cancer and to explore their roles in carcinogenesis of gastric cancer. [Methods] The expressions of SOX4 and p53 in 120 cases of paraffin-embedded gastric cancer samples and 30 cases of normal tissues were detected immunohistochemically. And the relationship of the expressions of SOX4 and p53 with gender,age,differentiation grade and depth of invasion were analyzed. [Results] The expressions of SOX4 and p53 in gastric cancer tissues（51.7% and 87.5%） were significantly higher than those in normal tissues（0 and 3.3%）（P〈0.05）. The expression of SOX4 in poorly differentiated gastric cancer group,61~76 years old age group and cancer stage Ⅱ group was significantly higher than that in well differentiated group,the other age groups and stage Ⅰa~Ⅰb group（P〈0.05）. The expression of p53 in stage Ⅱ group and stage Ⅲa~Ⅳ group was higher than that in stage Ⅰa~Ⅰb group（P 0.05）.There was no correlation between SOX4 and p53 expressions（r =2.30,P 0.05）.[Conclusion] SXO4 and p53 express highly in gastric cancer,and there is no correlation between them.SXO4 expression might correlate with the carcinogenesis of gastric cancer.