摘要
[目的]探讨术后复发晚期胃癌患者Her-2/neu表达及与临床病理特征和预后的相关性。[方法]分别采用免疫组织化学法(IHC)及荧光原位杂交法(FISH)对108例术后复发晚期胃癌患者进行Her-2/neu表达的检测,分析其与患者的年龄、性别、Lauren分型、组织学分级及与预后的相关性。[结果]108例患者中,IHC法检测Her-2/neu阳性表达13例,FISH法检测Her-2/neu阳性表达14例,两种方法均为阳性表达者10例,一致率为61.5%。15例正常胃黏膜中未见阳性表达。Her-2/neu表达与患者的年龄、性别、肿瘤部位、组织学分级、TNM分期、浸润深度、有无脉管浸润无关(P〉0.05),而与患者的Lauren分型、淋巴结转移有关(P〈0.05)。Her-2/neu阳性患者的中位疾病进展时间(TTP)为22.4个月(95%CI:23.44~26.55),阴性患者的中位TTP为25.0个月(95%CI:17.02~27.77),两者差异无统计学意义(P=0.215)。[结论 ]Her-2/neu可能是胃癌预后不良的标志之一。
[Purpose] To investigate the correlation of Her-2/neu expression with clinicopathologic features and prognosis in postoperative recurrent gastric cancer. [Methods] Her-2/neu expression was detected in 108 cases of advanced gastric cancer with recurrence postoperation by immunohistochemical method(IHC) and fluorescence in situ hybridization(FISH),and the correlation of Her-2/neu with age,gender,Lauren type,histological grade,prognosis was analyzed. [Results] Of108 patients,there were 13 cases with positive expression of Her-2/neu by IHC,14 cases with positive expression of Her-2/neu by FISH method. There were 10 cases with positive expression of Her-2/neu in both IHC and FISH,with consistent rate of 61.5%. No expression of Her-2/neu was found in 15 cases of normal gastric mucosa. No significant correlation was found between Her-2/neu expression and the patient's age,gender,tumor location,histological grade,TNM stage,depth of invasion,and vascular invasion(P〈0.05). There was significantly positive correlation between Her-2/neu expression and Lauren classification, lymph node metastasis(P〈0.05). Median time to progression(TTP) was 22.4 months in Her-2/neu positive patients(95%CI:23.44~26.55),and25.0 months(95% CI:17.02 ~27.77)in negative patients,without significant difference between them(P=0.215). [Conclusion] Her-2/neu might be a predictive indicator for poor prognosis in patients with recurrent gastric cancer.
出处
《肿瘤学杂志》
CAS
2015年第9期730-733,共4页
Journal of Chinese Oncology
基金
南通市科学技术局项目(S10910
W201009)