多肽脯氨酰顺反异构酶与阿尔茨海默病发病机制研究进展

Research progress of the impact of Pin1 on the pathogenesis of Alzheimer's disease

多肽脯氨酰顺反异构酶(Pin1)与多种神经变性病和肿瘤发病有关,特别是在阿尔茨海默病的发生与发展中具有重要作用。Pin1通过调节tau蛋白和β-淀粉样前体蛋白磷酸化过程,以及干扰细胞周期以影响阿尔茨海默病的发病。尽管目前大多数学者倾向于Pin1是神经保护因素,但也有学者认为其可能是促进神经元凋亡的因素,与PIN1基因多态性相关。因此,Pin1有可能成为治疗阿尔茨海默病的新靶点,并具备成为早期诊断阿尔茨海默病生物学标记的潜力。

Peptidyl-prolyl cis/trans isomerase（Pin1） has been identified as an important factor thatcan affect many neurodegenerative diseases as well as neoplasms. In particular, Pin1 has got a wideattention for its critical function in the occurence and development of Alzheimer＇s disease（AD）. It hasbeen found that Pin1 can affect the incidence of AD by adjusting the phosphorylation of tau andamyloid β- protein precursor（APP）, and interfering with the cell cycle. Although a lot of clinical datasuggest that Pin1 is a neuroprotective factor, some scholars point out that Pin1 may promote neuronalapoptosis, because of PIN1 gene polymorphism. In summary, Pin1 may become a new target for thetreatment of AD, and has the potential to be a biomarker for the early diagnosis of AD.