血清白介素15水平与冠心病冠状动脉病变严重程度的相关性

Correlation study on serum IL-15 and severity of coronary artery stenosis of coronary heart disease

目的分析血清白介素15(interleukin15,IL-15)水平与冠心病冠状动脉病变严重程度的相关性。方法选取我院心内科行冠脉造影检查的患者270例,采用Gensini评分评估冠脉狭窄严重程度,将患者按冠脉狭窄程度分为:正常组、轻度狭窄组、中度狭窄组和重度狭窄组(正常组Gensini=0;轻度组:0<Gensini≤18;中度组:18<Gensini≤41;重度组Gensini>41)。所有受试者接受问卷调查、体格测量、生化指标、收集各受试者临床资料及采用ELISA测定血清IL-15的浓度。运用多种统计分析方法,采用回归模型校正年龄,体质量指数,血脂,C反应蛋白,高血压病以及糖尿病等混杂因素,分析IL-15水平与冠心病冠脉病变严重程度的相关性。结果与冠脉造影正常组相比,冠脉狭窄患者血液中IL-15水平显著高于冠脉正常人群,并随冠状动脉狭窄的严重程度增加有逐渐增高的趋势〔正常:(6.7±2.0)ng/L,轻度狭窄:(11.9±3.1)ng/L,中度狭窄:(18.3±3.2)ng/L,重度狭窄:(24.4±4.0)ng/L;P<0.01〕。IL-15与Gensini评分呈正相关(r=0.572,P<0.01),这种关系在校正年龄,体质量指数,C反应蛋白,血脂,高血压病以及糖尿病等混杂因素后依然存在,是独立的相关因素。结论血清IL-15水平与冠脉狭窄程度呈正相关,血清IL-15水平是冠心病冠脉病变严重程度的独立相关因素。

AIM To assess the relationship between serum IL-15 and severity of coronary artery stenosis. METHODS Enrolled in this study were 270 subjects with suspected coronary heart disease who underwent coronary angiography （CAG）. Subjects were divided into normal group, mild group, moderate group and severe group according to the Gensini score （ normal ： Gensini = 0 ; mild ： 0 〈 Gensini ≤18 ; moderate ： 18 〈 Gensini ≤ 41; severe： Gensini 〉 41 ）. Clinical data were collected using questionnaires, physical measurements and biochemical indexes and enzyme-linked immunosorbent assay （ELISA） was used to determine serum IL-15 levels. Using multiple statistical analysis methods, we conducted analyses inclu- ding confounders and regression models adjusted for various measurements such as age, body mass index, lipid, C-reactive protein, hypertension and diabetes mutually for IL-15. RESULTS Compared with those in subjects without coronary stenosis, circulating IL-15 levels were significantly higher in subjects with stenosis with an increasing trend towards the severity of stenosis （normal： （6. 7 ± 2. 0） pg/ml,mild ： （ 11.9 ± 3.1 ） pg/ml, moderate ： （ 18.3 ± 3.2） pg/ml, and severe ： （ 24.4 ± 4.0） pg/ml ; P 〈 0. 01 ）. IL-15 was positively correlated with Gensini score （r =0. 572, P 〈0. 01 ） after adjusting for age, body mass index, lipid, C-reactive protein, hypertension and diabetes and was an independently related factor. CONCLUSION Serum IL-15 is higher in patients with coronary artery stenosis and is positively correlated with the severity of stenosis. These results indicate that serum IL-15 may be an independent related factor of coronary artery stenosis.