两种不同药物在脑外科麻醉诱导中对血流动力学的影响比较

The comparison of hemodynamic impact of two drugs on brain surgery anesthesia-induced patients

目的探析脑外科麻醉诱导时舒芬太尼的应用对血流动力学的影响。方法分析2012年3月至2015年1月在我院接受开颅手术治疗的68例患者的临床资料,随机分成观察组(舒芬太尼)和对照组(芬太尼)两组。比较两组患者的血流动力学的相关指标水平变化的情况。结果对照组患者的HR、DBP及SBP在T2、T3、T4时刻呈显著上升趋势,与观察组患者相应的指标相比,有统计学差异(P<0.05)。观察组患者在T2和T4时刻的血浆E、NE水平比对照组患者在相应时刻的水平高,有统计学差异(P<0.05)。结论在脑外科麻醉诱导时应用舒芬太尼可以使血流动力学的特征维持较为平稳的状态。

Objective Our retrospective study was aimed to investigate the hemodynamic impact of sufentanil on brain surgery anesthesia--induced patients. Methods Clinical data of patients received treatment of craniotomy operation at our hospital from 2012 to 2015 was retrospectively analyzed. Patients included were divided into two groups according to the treatment, observe group （Sufentanil） and control group （Fentanyl）. The changes of the levels of the related indexes of Hemodynamics between two groups was compared. Results The levels of HR,DBP and SBP of patients in observe group at T2, T3, T4 were significantly higher than those in control group, which had statistical differences. The levels of serum E and NE of patients in control group at T2 and T4were higher than those in observe group, which had statistical differences. Conclusion Su{entanil can effectively maintain stable hemodynamic characteristics on brain surgery anesthesia -induced patients.