基层孕前优生定量检测项目室内质控的现状分析

Internal quality control of quantitative assays related to pre-conception health in local settings

目的调查分析基层孕前优生实验室定量检测项目的室内质控开展现状，以提出改进建议。方法收集81家基层孕前优生实验室定量检测的室内质控数据，评估室内质控图表绘制的完整性、判断的正确性及各检测项目的不精密度（CV％）。结果81家基层孕前优生实验室定量检测项目中，已开展1～4个月室内质控的有47家（58．0％）；5个月及以上的有34家（42．0％），在这34家实验室中，室内质控图表填写完整的有20家（58．8％）、结果判断正确的有12家（35．3％）、在1565个项目次中有199个项目次的不精密度（12．7％）超过推荐值。结论部分基层孕前优生实验室质控结果未能正确、及时地判断和处理，一些项目的不精密度超过推荐值。建议在这些基层实验室中，加强技术人员的室内质控专题培训，以提高检验人员对室内质控结果的分析和判断能力；规范实验室操作，提高定量项目检测的精密度水平。

Objective To characterize the status of internal quality control for quantitative assays related to pre-conception health in local settings. Methods Data of internal quality control for quantitative assays from 81 local pre-conception health laboratories were collected.Integrity of the quality control charts,correctness of the judgment and imprecision of assays were analyzed. Results Forty-seven out of 81 （58.0%）laboratories had data of the preceding four months or shorter,and 34 of the 81 laboratories had data of 5 months or longer.In those 34 laboratories,20 （58.8%） had complete quality control charts,and 1 2 （35.3%）had correct judgment.One hundred and ninety-nine out of 1 565 （1 2.7%）assays did not reach the recommended imprecision level. Conclusion The internal quality control did not meet the requirement in term of timeliness,correctness and imprecision for some laboratory assays in local settings. Training is recommended to improve the quality of service.