急性脑梗死患者治疗前后血清Hcy、hs-CRP、BNP和血浆D-二聚体水平变化情况分析

Analysis of Hcy,hs-CRP,BNP and d-dimer in patients of acute cerebral infarction before and after treatment

目的探讨急性脑梗死患者治疗前后血清Hcy、hs-CRP、BNP和血浆D-二聚体(d-dimer,D-D)水平的变化与疾病诊断、治疗之间的关系及临床意义。方法选择2013年1月—2014年6月收治的急性脑梗死患者47例作为观察组,另选择同期在本院体检中心进行健康体检合格者40例作为对照组。检测并比较两组Hcy、hs-CRP、BNP和D-D水平及观察组治疗前后各指标变化情况。计量资料组间比较采用t检验,组内比较采用配对t检验,两变量关系采用Pearson相关分析,P<0.05为差异有统计学意义。结果观察组治疗前Hcy、hs-CRP、BNP和血浆D-D水平分别为(22.1±8.4)μmol/L、(3.3±1.2)mg/L、(31.4±16.2)pg/ml、(2.53±0.34)mg/L,明显高于对照组的(8.4±3.0)μmol/L、(1.0±0.49)mg/L、(9.2±5.1)pg/ml、(0.24±0.13)mg/L,差异均有统计学意义(均P<0.05)。观察组治疗后Hcy、hs-CRP、BNP和血浆D-D水平分别为(8.3±3.2)μmol/L、(1.1±0.5)mg/L、(9.6±5.9)pg/ml、(0.26±0.11)mg/L,较治疗前均明显降低,治疗前后比较差异均有统计学意义(均P<0.05)。血清Hcy水平与hs-CRP、BNP和血浆D-D水平呈正相关,差异均有统计学意义(r=0.6157、0.5283、0.5832,均P<0.05)。结论 Hcy、hs-CRP、BNP、D-D是反映病情发展的良好的实验室指标,检测其水平变化对指导急性脑梗死的诊断、临床治疗及预后判断具有重要的临床意义。

Objective To study the changes of Hcy,hs-CRP,BNP,and d-dimer（D-D） levels before and after treatment in acute cerebral infarct patients.The relationship between disease diagnosis,treatment and clinical significance with above indexes were explored.Methods 47 cases of acute cerebral infarction patients from January 2013 to June 2014 were＇ selected as observation group,40 cases of healthy people were selected as control group.The levels of Hcy,hs-CRP,BNP and D-D of the two groups were tested and compared.Comparison of measurement data between groups using t test,in group were compared with paired t test,relationships between the two variables using Pearson correlation analysis,P〈0.05 was considered statistically significant.Re- suits The levels of Hcy,hs-CRP, BNP and D-D of observation group before treatment were （22.1 ± 8.4）μmol/L,（3.3 ± 1.2）mg/L, （31.4 ± 16.2）pg/ml,（2.53 ± 0.34）mg/L, higher than that of the control group [（8.4 ± 3.0）μmol/L,（1.0 ＋ 0.49）mg/L,（9.2 ± 5.1）pg/ml, （0.24 ± 0.13）mg/L）],differences were statistically significant（all P〈0.05）.The levels of Hcy,hs-CRP, BNP and D-D of observation group after treatment were （8.3 ± 3.2）μmol/L （1.1 ± 0.5）mg/L,（9.6 ± 5.9）pg/ml,（0.26 ± 0.11）mg/L,lower than that before treat- ment,differences were statistically significant（all P〈0.05）.The level of Hcy was positively correlated with hs-CRP, BNP and D-D, differences were statistically significant（r=0.6157,0.5283,0.5832,all P〈0.05）.Conclusion The levels of Hcy,hs-CRP,BNP and D-D were good laboratory indexed reaction disease development.There were great clinical significance in the guidance for the di- agnosis of acute cerebral infarction,treatment and prognosis.