摘要
血管生成素及其受体Tie2是近年来发现的血管生成调节因子,在肿瘤血管新生中具有促进血管稳定、成熟和重建的作用。最新研究证实,血管生成素及其受体Tie2在白血病中异常表达,与白血病的细胞形态、免疫分型、核型及预后等因素相关,并且在白血病的治疗中发挥着重要的作用,对白血病的预后也有一定的意义。由此表明,研究血管生成素及其受体Tie2在白血病中的表达及其病理生理机制,将有利于白血病治疗的进展。现结合相关参考文献与临床试验对血管生成素及其受体Tie2在白血病中的研究现状进行如下综述。
Angiogenesis and its receptor Tie2-is a regulator of angiogenesis in recent years. It has the effect of promoting blood vessel stability, maturation and reconstruction in tumor angiogenesis. Recent studies have demonstrated that the expression of Tie2 in leukemia is associated with the abnormal expression of leukemia cells, which is associated with the cell morphology, immune typing and prognosis, and plays an important role in the treatment of leukemia. It is indicated that the expression of Tie2 in leukemia and its pathophysiological mechanism will be beneficial to the development of leukemia treatment, This paper reviews the current research status of Tie2 in leukemia by combining the relevant references and clinical trials.
出处
《药品评价》
CAS
2015年第14期28-32,共5页
Drug Evaluation
