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探讨事件相关电位P300在氯胺酮依赖者认知功能检测中的应用及对疗效评估的价值

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摘要 目的研究探讨事件相关电位P300在氯胺酮依赖者认知功能检测中的应用及对疗效评估的价值。方法选取氯胺酮依赖者45例作为观察组,并随机抽取45例健康者作为对照组,对两组研究对象均通过P300测试以及蒙特利尔认知功能评估表进行相关评定、对比。结果观察组CZ、PZ点潜伏期明显长于对照组,差异有统计学意义(t=3.2149,P=0.0018<0.05);另外观察组CZ、PZ点波幅明显低于对照组,差异有统计学意义(t=4.8340,P=0.0000<0.05);观察组蒙特利尔认知功能各项能力评分均低于对照组,差异显著有统计学意义(t=27.6433,P=0.0000<0.05)。结论在氯胺酮依赖者认知功能检测中的应用事件相关电位P300效果良好,具有较高的应用价值。
作者 李芳
出处 《中国实用医药》 2015年第24期152-153,共2页 China Practical Medicine
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  • 1王艳芬,刘志民.我国“新型毒品”的滥用特征及其危害[J].中国药物滥用防治杂志,2007,13(2):63-66. 被引量:98
  • 2Morgan CJ,Riccelli M,Maitland CH,et al.Long-term elects of ketamine: evidence for a persisting impairment of source memory in recreationalusers [J].Drug Alcohol Depend, 2004,75(3):301-308.
  • 3Lim DK. Ketamine Associated Psychedelic Effects and Dependence[J]. Singapore Med J, 2003, 44(1):31-34.
  • 4Stone JM, Erlandsson K, Arstad E,et al. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy-a [123I]CNS-1261 SPET study[J]. Psychopharmacology,2008,197(3) :401-408.
  • 5Honey GD,Loughlin CO,Turner DC,et al. The Effects of a Subpsychotic Dose of Ketamine on Recognition and Source Memory for Agency: Implications for Pharmacological Modelling of Core Symptoms of Schizophrenia [J]. Neuropsychopharrnacology,2006,31 (4):413 -423.
  • 6Morgan CJA,Curran HV. Acute and chronic effects of ketamine upon human memory: a review [J]. Psychopharmacology,2006,188(4):408-424.
  • 7Lofwall MR, Griffiths RR, Mintzer MZ. Cognitive and Subjective Acute Dose Effects of Intramuscular Ketamine in Healthy Adults [J]. Experimental and Clinical Psychopharmacology,2006,14(4):439-449.
  • 8Curran HA, Monaghan L. In and out of the K-hole: a comparison of the acute and residual effects ofketamine in frequent and infrequent ketamine users[J]. Addiction,2001,96 (5):749-760.
  • 9Morgan CJ, Muetzelfeldt L, Curran HV.Ketamine use, cognition and psychological wellbeing: a comparison of frequent, infrequent and ex-users with polydrug and non-using controls.Addiction,2009,104(1):77-87.
  • 10Weickert TW, Goldberg TE, Marenco S, et al. Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confounds. Neuropsychopharmacology, 2003,28 (12):2217-2218.

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