雌激素在糖尿病胃轻瘫中的作用

Role of estrogen in diabetic gastroparesis

胃轻瘫是临床常见的胃动力障碍性疾病,以非梗阻因素导致的胃排空延迟为特点,伴有一系列上消化道症状.糖尿病胃轻瘫(diabetic gastroparesis,DGP)是糖尿病的重要并发症之一,严重损害患者的生活质量.目前,DGP的发病机制尚不明确.DGP患者中女性居多,并且女性患者的症状随体内雌激素水平的波动而变化,推测雌激素可影响胃运动.胃排空是诊断胃轻瘫的客观指标,本文就DGP以及雌激素对胃排空的可能作用机制就现有文献进行综述.

Gastroparesis is a highly prevalent chronic disorder of the stomach,which is characterized by delayed gastric emptying and accompanied by a series of upper gastrointestinal symptoms.Diabetic gastroparesis（DGP） is one of the severe complications of diabetes,seriously affecting the patient＇s quality of life.At present,the pathogenesis of DGP is still unclear.The majority of DGP patients are women,and women＇s symptoms change with the fluctuation of the level of estrogen.Therefore,we speculate that estrogen may play an vital role in the stomach motility.Gastric emptying is an objective index for the diagnosis of gastroparesis.This article reviews the role of estrogen in DGP and the possible mechanisms.